TY - JOUR
T1 - Eosinophilic Granuloma Showing Rapid Regression: Report of a Mandibular Case with Application of a Modified PNA Staining Method for Demonstration of Langerhans-type Histiocytes
AU - Kitano, Motoo
AU - Landini, Gabriel
AU - Semba, Ichiro
AU - Urago, Atsushi
AU - Sugihara, Kazumasa
AU - Mukai, Hiroshi
AU - Yamashita, Sukehide
PY - 1990/8
Y1 - 1990/8
N2 - A mandibular eosinophilic granuloma in a 16-year-old male is reported. This case showed rapid regression, which was clearly demonstrated by histopathological examinations of both preoperative biopsy and surgical materials. Transformation from an eosinophilic granuloma to a xanthomatous granuloma with multinucleated giant cells was observed after only 26 days. Special staining of paraffin sections with peanut agglutinin (PNA) and use of electron microscopy showed that the main component of the lesion in the biopsy material was Langerhans-type histiocytes. These cells had disappeared from the lesion by the time of the operation. At the same time, the number of infiltrating eosinophils was also markedly reduced. It seems appropriate to consider that the rapid regression of this disease was correlated with the rapid reduction in the number of Langerhans type histiocytes appearing in the granulomatous foci, as well as the number of infiltrating eosinophils.
AB - A mandibular eosinophilic granuloma in a 16-year-old male is reported. This case showed rapid regression, which was clearly demonstrated by histopathological examinations of both preoperative biopsy and surgical materials. Transformation from an eosinophilic granuloma to a xanthomatous granuloma with multinucleated giant cells was observed after only 26 days. Special staining of paraffin sections with peanut agglutinin (PNA) and use of electron microscopy showed that the main component of the lesion in the biopsy material was Langerhans-type histiocytes. These cells had disappeared from the lesion by the time of the operation. At the same time, the number of infiltrating eosinophils was also markedly reduced. It seems appropriate to consider that the rapid regression of this disease was correlated with the rapid reduction in the number of Langerhans type histiocytes appearing in the granulomatous foci, as well as the number of infiltrating eosinophils.
U2 - 10.1111/j.1440-1827.1990.tb01604.x
DO - 10.1111/j.1440-1827.1990.tb01604.x
M3 - Article
SN - 1320-5463
SP - 588
EP - 595
JO - Pathology International
JF - Pathology International
ER -