Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

Ignacio Insua, Evangelos Liamas, Zhenyu Zhang, Anna F. A. Peacock, Anne Marie Krachler, Francisco Fernandez-trillo

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
135 Downloads (Pure)

Abstract

Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance.
Original languageEnglish
Pages (from-to)2684-2690
JournalPolymer Chemistry
Volume2016
Issue number15
Early online date16 Mar 2016
DOIs
Publication statusPublished - 16 Jun 2016

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