Enteropathogenic E.coli type III effectors EspG and espG2 disrupt the microtubule network of intestinal epithelial cells

Robert Shaw, K Smallett, Jennifer Cleary, J Garmendia, Anna Straatman-Iwanowska, G Frankel, Stuart Knutton

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.
Original languageEnglish
Pages (from-to)4385-4390
Number of pages6
JournalInfection and Immunity
Volume73
DOIs
Publication statusPublished - 1 Jan 2005

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