Enhancement of Selectivity of an Organometallic Anticancer Agent by Redox Modulation

Isolda Romero-Canelón, Magdalena Mos, Peter J. Sadler

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Combination with redox modulators can potentiate the anticancer activity and maximize the selectivity of organometallic complexes with redox-based mechanisms of action. We show that nontoxic doses of l-buthionine sulfoximine increase the selectivity of organo-Os complex FY26 for human ovarian cancer cells versus normal lung fibroblasts to 63-fold. This increase is not due to changes in the mechanism of action of FY26 but to the decreased response of cancer cells to oxidative stress.
Original languageEnglish
Pages (from-to)7874-7880
JournalJournal of Medicinal Chemistry
Volume58
Issue number19
Early online date23 Sep 2015
DOIs
Publication statusPublished - 8 Oct 2015

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