Enhanced co-stimulatory ability of synovial fluid accessory cells in rheumatoid arthritis

S E Robertson, S P Young, N J Viner, P A Bacon

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8 Citations (Scopus)


We have established in vitro assays that allow the examination of co-stimulatory function of rheumatoid arthritis (RA) antigen-presenting cells (APC). Synovial fluid (SF) and peripheral blood (PB) APC co-stimulatory ability was compared in the activation of peptide-specific human T-cell clones. T-cell receptor (TCR) stimulation by peptide or anti-CD3 antibody allowed the direct comparison of SF and PB APC co-stimulatory activity, separately from their ability to process antigen. SF APC from 15 RA patients consistently enhanced T-cell proliferation when compared to their PB counterparts. Moreover, increasing the numbers of PB APC present resulted in only a minor increase in T-cell proliferation, failing to achieve levels stimulated by SF APC. We propose that the enhanced co-stimulatory function of synovial APC may be a significant factor in the persistence of local immune responses in RA.
Original languageEnglish
Pages (from-to)413-9
Number of pages7
JournalRheumatology (Oxford)
Issue number4
Publication statusPublished - Apr 1997


  • Phenotype
  • Lymphocyte Activation
  • Clone Cells
  • Humans
  • Arthritis, Rheumatoid
  • Peptides
  • Synovial Fluid
  • Antigen-Presenting Cells
  • Epitopes
  • T-Lymphocytes


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