Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells

Mahban Irandoust; Julian Alvarez Zarate; Isabelle Hubeek; Ellen M van Beek; Karin Schornagel; Aart J F Broekhuizen; Mercan Akyuz; Arjan A van de Loosdrecht; Ruud Delwel; Peter J Valk; Edwin Sonneveld; Pamela Kearns; Ursula Creutzig; Dirk Reinhardt; Eveline S J M de Bont; Eva A Coenen; Marry M van den Heuvel-Eibrink; C Michel Zwaan; Gertjan J L Kaspers; Jacqueline Cloos; Timo K van den Berg

doi:10.1371/journal.pone.0052143

Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells

Mahban Irandoust
, Julian Alvarez Zarate
, Isabelle Hubeek
, Ellen M van Beek
, Karin Schornagel
, Aart J F Broekhuizen
, Mercan Akyuz
, Arjan A van de Loosdrecht
, Ruud Delwel
, Peter J Valk
, Edwin Sonneveld
, Pamela Kearns
, Ursula Creutzig
, Dirk Reinhardt
, Eveline S J M de Bont
, Eva A Coenen
, Marry M van den Heuvel-Eibrink
, C Michel Zwaan
, Gertjan J L Kaspers
, Jacqueline Cloos

Timo K van den Berg

Cancer Research UK Clinical Trials Unit

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

305 Downloads (Pure)

Abstract

Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the SIRPα in acute myeloid leukemia.

Original language	English
Pages (from-to)	e52143
Journal	PLoS ONE
Volume	8
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0052143
Publication status	Published - 8 Jan 2013

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© 2013 Irandoust et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Eligibility for repository checked June 2015
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Irandoust, M., Alvarez Zarate, J., Hubeek, I., van Beek, E. M., Schornagel, K., Broekhuizen, A. J. F., Akyuz, M., van de Loosdrecht, A. A., Delwel, R., Valk, P. J., Sonneveld, E., Kearns, P., Creutzig, U., Reinhardt, D., de Bont, E. S. J. M., Coenen, E. A., van den Heuvel-Eibrink, M. M., Zwaan, C. M., Kaspers, G. J. L., ... van den Berg, T. K. (2013). Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells. PLoS ONE, 8(1), e52143. https://doi.org/10.1371/journal.pone.0052143

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title = "Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells",

abstract = "Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the SIRPα in acute myeloid leukemia.",

author = "Mahban Irandoust and \{Alvarez Zarate\}, Julian and Isabelle Hubeek and \{van Beek\}, \{Ellen M\} and Karin Schornagel and Broekhuizen, \{Aart J F\} and Mercan Akyuz and \{van de Loosdrecht\}, \{Arjan A\} and Ruud Delwel and Valk, \{Peter J\} and Edwin Sonneveld and Pamela Kearns and Ursula Creutzig and Dirk Reinhardt and \{de Bont\}, \{Eveline S J M\} and Coenen, \{Eva A\} and \{van den Heuvel-Eibrink\}, \{Marry M\} and Zwaan, \{C Michel\} and Kaspers, \{Gertjan J L\} and Jacqueline Cloos and \{van den Berg\}, \{Timo K\}",

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Irandoust, M, Alvarez Zarate, J, Hubeek, I, van Beek, EM, Schornagel, K, Broekhuizen, AJF, Akyuz, M, van de Loosdrecht, AA, Delwel, R, Valk, PJ, Sonneveld, E, Kearns, P, Creutzig, U, Reinhardt, D, de Bont, ESJM, Coenen, EA, van den Heuvel-Eibrink, MM, Zwaan, CM, Kaspers, GJL, Cloos, J & van den Berg, TK 2013, 'Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells', PLoS ONE, vol. 8, no. 1, pp. e52143. https://doi.org/10.1371/journal.pone.0052143

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T1 - Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells

AU - Irandoust, Mahban

AU - Alvarez Zarate, Julian

AU - Hubeek, Isabelle

AU - van Beek, Ellen M

AU - Schornagel, Karin

AU - Broekhuizen, Aart J F

AU - Akyuz, Mercan

AU - van de Loosdrecht, Arjan A

AU - Delwel, Ruud

AU - Valk, Peter J

AU - Sonneveld, Edwin

AU - Kearns, Pamela

AU - Creutzig, Ursula

AU - Reinhardt, Dirk

AU - de Bont, Eveline S J M

AU - Coenen, Eva A

AU - van den Heuvel-Eibrink, Marry M

AU - Zwaan, C Michel

AU - Kaspers, Gertjan J L

AU - Cloos, Jacqueline

AU - van den Berg, Timo K

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AB - Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the SIRPα in acute myeloid leukemia.

U2 - 10.1371/journal.pone.0052143

DO - 10.1371/journal.pone.0052143

M3 - Article

C2 - 23320069

SN - 1932-6203

VL - 8

SP - e52143

JO - PLoS ONE

JF - PLoS ONE

IS - 1

ER -

Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells

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