TY - JOUR
T1 - Engagement of SIRPα Inhibits Growth and Induces Programmed Cell Death in Acute Myeloid Leukemia Cells
AU - Irandoust, Mahban
AU - Alvarez Zarate, Julian
AU - Hubeek, Isabelle
AU - van Beek, Ellen M
AU - Schornagel, Karin
AU - Broekhuizen, Aart J F
AU - Akyuz, Mercan
AU - van de Loosdrecht, Arjan A
AU - Delwel, Ruud
AU - Valk, Peter J
AU - Sonneveld, Edwin
AU - Kearns, Pamela
AU - Creutzig, Ursula
AU - Reinhardt, Dirk
AU - de Bont, Eveline S J M
AU - Coenen, Eva A
AU - van den Heuvel-Eibrink, Marry M
AU - Zwaan, C Michel
AU - Kaspers, Gertjan J L
AU - Cloos, Jacqueline
AU - van den Berg, Timo K
PY - 2013/1/8
Y1 - 2013/1/8
N2 - Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the SIRPα in acute myeloid leukemia.
AB - Recent studies show the importance of interactions between CD47 expressed on acute myeloid leukemia (AML) cells and the inhibitory immunoreceptor, signal regulatory protein-alpha (SIRPα) on macrophages. Although AML cells express SIRPα, its function has not been investigated in these cells. In this study we aimed to determine the role of the SIRPα in acute myeloid leukemia.
U2 - 10.1371/journal.pone.0052143
DO - 10.1371/journal.pone.0052143
M3 - Article
C2 - 23320069
SN - 1932-6203
VL - 8
SP - e52143
JO - PLoS ONE
JF - PLoS ONE
IS - 1
ER -