Endoscopic, rapid near-infrared optical tomography

Daqing Piao, Hao Xie, Weili Zhang, Jerzy S Krasinski, Guolong Zhang, Hamid Dehghani, Brian W Pogue

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.

Original languageEnglish
Pages (from-to)2876-8
Number of pages3
JournalOptics Letters
Issue number19
Publication statusPublished - 1 Oct 2006


  • Computer Systems
  • Endoscopes
  • Equipment Design
  • Equipment Failure Analysis
  • Fiber Optic Technology
  • Image Enhancement
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectrophotometry, Infrared
  • Tomography, Optical Coherence


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