Abstract
This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source-detector fibers for tomography as well as parallel sampling of all source-detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.
| Original language | English |
|---|---|
| Pages (from-to) | 2876-8 |
| Number of pages | 3 |
| Journal | Optics Letters |
| Volume | 31 |
| Issue number | 19 |
| Publication status | Published - 1 Oct 2006 |
Keywords
- Computer Systems
- Endoscopes
- Equipment Design
- Equipment Failure Analysis
- Fiber Optic Technology
- Image Enhancement
- Phantoms, Imaging
- Reproducibility of Results
- Sensitivity and Specificity
- Spectrophotometry, Infrared
- Tomography, Optical Coherence
