Encephalopathy with staphylococcal endocarditis: multiple neuropathological findings

SG Weeks, C Silva, RN Auer, CJ Doig, Martin Gill, C Power

Research output: Contribution to journalArticle

8 Citations (Scopus)


BACKGROUND: Infective endocarditis is associated with serious neurological sequelae. OBJECTIVE: Here, we report a patient with Staphylococcus aureus endocarditis, secondary to congenital heart disease, with subacute onset of multiple neurological complications. RESULTS: Despite prompt antibiotic treatment with rapid sterilization of blood cultures, the patient died with brain herniation within 96 hours of admission. Neuropathological examination showed intraparenchymal hemorrhages, mycotic aneurysms, micro-abscesses and septic arteritis with accompanying infarction. Immunocytochemical studies revealed enhanced CD45 and GFAP immunoreactivity, together with adenosine A1 receptor detection on macrophages and microglia. CONCLUSIONS: Infective endocarditis is associated with multiple neuropathological lesions, which may contribute to its poor clinical outcome and activation of cells of monocyte-microglial lineage throughout the brain.
Original languageEnglish
Pages (from-to)260-4
Number of pages5
JournalCan.J. Neurol.Sci
Issue number3
Publication statusPublished - 1 Jan 2001


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