Eliminating irreproducibility in SERS substrates

David‐Benjamin Grys, Rohit Chikkaraddy, Marlous Kamp, Oren A. Scherman, Jeremy J. Baumberg, Bart Nijs

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Irreproducibility in surface-enhanced Raman spectroscopy (SERS) due to variability among substrates is a source of recurrent debate within the field. It is regarded as a major hurdle towards the widespread adoption of SERS as a sensing platform. Most of the literature focused on developing substrates for various applications considers reproducibility of lower importance. Here, we address and analyse the sources of this irreproducibility in order to show how these can be minimised. We apply our findings to a simple substrate demonstrating reproducible SERS measurements with relative standard deviations well below 1% between different batches and days. Identifying the sources of irreproducibility and understanding how to reduce these can aid in the transition of SERS from the lab to real-world applications.
Original languageEnglish
Pages (from-to)412-419
JournalJournal of Raman Spectroscopy
Issue number2
Early online date28 Oct 2020
Publication statusPublished - Feb 2021


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