TY - JOUR
T1 - Elevated platelet microparticles in stable coronary artery disease are unrelated to disease severity or to indices of inflammation
AU - Tan, KT
AU - Tayebjee, Muzahir
AU - Macfadyen, Robert
AU - Lip, Gregory
AU - Blann, Andrew
PY - 2005/9/1
Y1 - 2005/9/1
N2 - Platelet microparticles (PMPs), procoagulant membrane vesicles derived from activated platelets, are elevated in acute myocardial infarction and unstable angina but their relationship to inflammation and indices of coronary artery disease are unclear. We therefore hypothesised that PMPs are related to scores of coronary atheroma and/or coronary stenosis. Our study was completed by comparing PMP data with other platelet markers and with hs-CRP, marking inflammation. We recruited 54 patients attending for coronary angiography, comparing them to 35 age- and sex-matched controls. Peripheral blood was analysed for PMPs, percent platelets positive for CD62P and CD63 (all flow cytometry), soluble P selectin and hsCRP (both immunoassay). Patients exhibited higher PMPs, increased platelet %CD62P, %CD63 and soluble P selectin (all P <0.01) and hs-CRP (P = 0.0167) than healthy controls. However, analysing only patients with an unequivocal classification, there were no significant (P
AB - Platelet microparticles (PMPs), procoagulant membrane vesicles derived from activated platelets, are elevated in acute myocardial infarction and unstable angina but their relationship to inflammation and indices of coronary artery disease are unclear. We therefore hypothesised that PMPs are related to scores of coronary atheroma and/or coronary stenosis. Our study was completed by comparing PMP data with other platelet markers and with hs-CRP, marking inflammation. We recruited 54 patients attending for coronary angiography, comparing them to 35 age- and sex-matched controls. Peripheral blood was analysed for PMPs, percent platelets positive for CD62P and CD63 (all flow cytometry), soluble P selectin and hsCRP (both immunoassay). Patients exhibited higher PMPs, increased platelet %CD62P, %CD63 and soluble P selectin (all P <0.01) and hs-CRP (P = 0.0167) than healthy controls. However, analysing only patients with an unequivocal classification, there were no significant (P
U2 - 10.1080/00207230500120401
DO - 10.1080/00207230500120401
M3 - Article
C2 - 16194867
SN - 1369-1635
SN - 1369-1635
SN - 1369-1635
SN - 1369-1635
SN - 1369-1635
SN - 1369-1635
SN - 1369-1635
SN - 1369-1635
VL - 16
SP - 368
EP - 371
JO - Platelets
JF - Platelets
IS - 6
ER -