Electrochemical and PM-IRRAS Studies of the Effect of Cholesterol on the Structure of a DMPC Bilayer supported at an Au(111) Electrode Surface, Part 1: Properties of the Acyl Chains

X Bin; Sarah Horswell; J Lipkowski

doi:10.1529/biophysj.104.058347

Electrochemical and PM-IRRAS Studies of the Effect of Cholesterol on the Structure of a DMPC Bilayer supported at an Au(111) Electrode Surface, Part 1: Properties of the Acyl Chains

X Bin, Sarah Horswell, J Lipkowski

Chemistry

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Abstract

Charge density measurements and polarization modulation infrared reflection absorption spectroscopy were employed to investigate the spreading of small unilamellar vesicles of a dimyristoylphosphatidylcholine (DMPC)/cholesterol (7:3 molar ratio) mixture onto an Au (111) electrode surface. The electrochemical experiments demonstrated that vesicles fuse and spread onto the Au (111) electrode surface, forming a bilayer, at rational potentials -0.4 V <(E - Epzc) <0.4 V or field strength

Original language	English
Pages (from-to)	592-604
Number of pages	13
Journal	Biophysical Journal
Volume	89
DOIs	https://doi.org/10.1529/biophysj.104.058347
Publication status	Published - 1 Jan 2005

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abstract = "Charge density measurements and polarization modulation infrared reflection absorption spectroscopy were employed to investigate the spreading of small unilamellar vesicles of a dimyristoylphosphatidylcholine (DMPC)/cholesterol (7:3 molar ratio) mixture onto an Au (111) electrode surface. The electrochemical experiments demonstrated that vesicles fuse and spread onto the Au (111) electrode surface, forming a bilayer, at rational potentials -0.4 V <(E - Epzc) <0.4 V or field strength ",

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Electrochemical and PM-IRRAS Studies of the Effect of Cholesterol on the Structure of a DMPC Bilayer supported at an Au(111) Electrode Surface, Part 1: Properties of the Acyl Chains

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