Efficacy and complications of pituitary irradiation

Georgia Ntali, Niki Karavitaki

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
246 Downloads (Pure)


Radiation therapy is widely used in the management of intracranial (including sellar and parasellar) and systemic disorders. Although in many cases the irradiation aims to prevent the growth or regrowth and to control the hormonal hypersecretion of a pituitary tumor, in many others it adversely affects the hypothalamo-pituitary function simply because this area receives significant doses of radiation delivered for non-hypothalamo-pituitary disorders. The main long-term complications include hypopituitarism, optic neuropathy, cerebrovascular morbidity, and second brain tumors. Radiation technique and schedule are important determinants of these adverse effects.

Original languageEnglish
Pages (from-to)117-26
Number of pages10
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
Early online date4 Nov 2014
Publication statusPublished - Mar 2015


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