Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease

S Hayat; Girish Dwivedi; A Jacobsen; T Lim; C Kinsey; R Senior

doi:10.1161/CIRCULATIONAHA.107.726711

Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease

S Hayat, Girish Dwivedi, A Jacobsen, T Lim, C Kinsey, R Senior

Research output: Contribution to journal › Article

59 Citations (Scopus)

Abstract

BACKGROUND: We aimed to investigate the cardiac effects of left bundle-branch block (LBBB) using myocardial contrast echocardiography (MCE) to ascertain the value of MCE for detecting coronary artery disease (CAD) and to uncover the mechanism that affects the accuracy of single-photon emission computed tomography (SPECT) in these patients. METHODS AND RESULTS: Sixty-three symptomatic LBBB patients (group A), 10 left ventricular ejection fraction-matched control subjects without LBBB and no CAD (group B), and 10 normal control subjects (group C) underwent resting echocardiography. Rest and vasodilator MCE and SPECT were undertaken in LBBB patients. Septal (SW) and posterior wall (PW) thickness, thickening, quantitative myocardial blood flow (MBF), and MBF reserve were measured. SW/PW thickness and percentage thickening ratios were lower (P

Original language	English
Pages (from-to)	1832-1841
Number of pages	10
Journal	Circulation
Volume	117
Issue number	14
Early online date	8 Apr 2008
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.107.726711
Publication status	Published - 8 Apr 2008

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Hayat, S., Dwivedi, G., Jacobsen, A., Lim, T., Kinsey, C., & Senior, R. (2008). Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease. Circulation, 117(14), 1832-1841. https://doi.org/10.1161/CIRCULATIONAHA.107.726711

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abstract = "BACKGROUND: We aimed to investigate the cardiac effects of left bundle-branch block (LBBB) using myocardial contrast echocardiography (MCE) to ascertain the value of MCE for detecting coronary artery disease (CAD) and to uncover the mechanism that affects the accuracy of single-photon emission computed tomography (SPECT) in these patients. METHODS AND RESULTS: Sixty-three symptomatic LBBB patients (group A), 10 left ventricular ejection fraction-matched control subjects without LBBB and no CAD (group B), and 10 normal control subjects (group C) underwent resting echocardiography. Rest and vasodilator MCE and SPECT were undertaken in LBBB patients. Septal (SW) and posterior wall (PW) thickness, thickening, quantitative myocardial blood flow (MBF), and MBF reserve were measured. SW/PW thickness and percentage thickening ratios were lower (P",

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Hayat, S, Dwivedi, G, Jacobsen, A, Lim, T, Kinsey, C & Senior, R 2008, 'Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease', Circulation, vol. 117, no. 14, pp. 1832-1841. https://doi.org/10.1161/CIRCULATIONAHA.107.726711

Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease. / Hayat, S; Dwivedi, Girish; Jacobsen, A et al.

In: Circulation, Vol. 117, No. 14, 08.04.2008, p. 1832-1841.

Research output: Contribution to journal › Article

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T1 - Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease

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AU - Dwivedi, Girish

AU - Jacobsen, A

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AU - Kinsey, C

AU - Senior, R

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AB - BACKGROUND: We aimed to investigate the cardiac effects of left bundle-branch block (LBBB) using myocardial contrast echocardiography (MCE) to ascertain the value of MCE for detecting coronary artery disease (CAD) and to uncover the mechanism that affects the accuracy of single-photon emission computed tomography (SPECT) in these patients. METHODS AND RESULTS: Sixty-three symptomatic LBBB patients (group A), 10 left ventricular ejection fraction-matched control subjects without LBBB and no CAD (group B), and 10 normal control subjects (group C) underwent resting echocardiography. Rest and vasodilator MCE and SPECT were undertaken in LBBB patients. Septal (SW) and posterior wall (PW) thickness, thickening, quantitative myocardial blood flow (MBF), and MBF reserve were measured. SW/PW thickness and percentage thickening ratios were lower (P

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Hayat S, Dwivedi G, Jacobsen A, Lim T, Kinsey C, Senior R. Effects of Left Bundle-Branch Block on Cardiac Structure, Function, Perfusion, and Perfusion Reserve: Implications for Myocardial Contrast Echocardiography Versus Radionuclide Perfusion Imaging for the Detection of Coronary Artery Disease. Circulation. 2008 Apr 8;117(14):1832-1841. Epub 2008 Apr 8. doi: 10.1161/CIRCULATIONAHA.107.726711