Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

M Schmitt; P Gunaruwan; N Payne; L Lee; AJ Broadley; AK Nightingale; JR Cockcroft; AD Struthers; JV Tyberg; Michael Frenneaux; Justin S W Taylor

doi:10.1161/01.ATV.zhq0504.7914

Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

M Schmitt
, P Gunaruwan
, N Payne
, L Lee
, AJ Broadley
, AK Nightingale
, JR Cockcroft
, AD Struthers
, JV Tyberg
, Michael Frenneaux
, Justin S W Taylor

Birmingham Medical School

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

OBJECTIVE: Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects. METHODS AND RESULTS: Venous and arterial forearm vascular responses to incremental intra-arterial doses of ANP, Urodilatin, BNP, CNP, or the ANP receptor antagonist A71915 were studied in 53 patients and 11 controls. ANP receptor antagonism reduced FVV by 4.4%+/-1.2% (P

Original language	English
Pages (from-to)	911-917
Number of pages	7
Journal	Arteriosclerosis Thrombosis and Vascular Biology
Volume	24
DOIs	https://doi.org/10.1161/01.ATV.zhq0504.7914
Publication status	Published - 1 Jan 2004

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Schmitt, M., Gunaruwan, P., Payne, N., Lee, L., Broadley, AJ., Nightingale, AK., Cockcroft, JR., Struthers, AD., Tyberg, JV., Frenneaux, M., & Taylor, J. S. W. (2004). Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure. Arteriosclerosis Thrombosis and Vascular Biology, 24, 911-917. https://doi.org/10.1161/01.ATV.zhq0504.7914

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title = "Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure",

abstract = "OBJECTIVE: Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects. METHODS AND RESULTS: Venous and arterial forearm vascular responses to incremental intra-arterial doses of ANP, Urodilatin, BNP, CNP, or the ANP receptor antagonist A71915 were studied in 53 patients and 11 controls. ANP receptor antagonism reduced FVV by 4.4\%+/-1.2\% (P",

author = "M Schmitt and P Gunaruwan and N Payne and L Lee and AJ Broadley and AK Nightingale and JR Cockcroft and AD Struthers and JV Tyberg and Michael Frenneaux and Taylor, \{Justin S W\}",

year = "2004",

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doi = "10.1161/01.ATV.zhq0504.7914",

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Schmitt, M, Gunaruwan, P, Payne, N, Lee, L, Broadley, AJ, Nightingale, AK, Cockcroft, JR, Struthers, AD, Tyberg, JV, Frenneaux, M & Taylor, JSW 2004, 'Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure', Arteriosclerosis Thrombosis and Vascular Biology, vol. 24, pp. 911-917. https://doi.org/10.1161/01.ATV.zhq0504.7914

TY - JOUR

T1 - Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

AU - Schmitt, M

AU - Gunaruwan, P

AU - Payne, N

AU - Lee, L

AU - Broadley, AJ

AU - Nightingale, AK

AU - Cockcroft, JR

AU - Struthers, AD

AU - Tyberg, JV

AU - Frenneaux, Michael

AU - Taylor, Justin S W

PY - 2004/1/1

Y1 - 2004/1/1

N2 - OBJECTIVE: Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects. METHODS AND RESULTS: Venous and arterial forearm vascular responses to incremental intra-arterial doses of ANP, Urodilatin, BNP, CNP, or the ANP receptor antagonist A71915 were studied in 53 patients and 11 controls. ANP receptor antagonism reduced FVV by 4.4%+/-1.2% (P

AB - OBJECTIVE: Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects. METHODS AND RESULTS: Venous and arterial forearm vascular responses to incremental intra-arterial doses of ANP, Urodilatin, BNP, CNP, or the ANP receptor antagonist A71915 were studied in 53 patients and 11 controls. ANP receptor antagonism reduced FVV by 4.4%+/-1.2% (P

UR - https://www.scopus.com/pages/publications/2442559304

U2 - 10.1161/01.ATV.zhq0504.7914

DO - 10.1161/01.ATV.zhq0504.7914

M3 - Article

C2 - 15001459

SN - 1524-4636

VL - 24

SP - 911

EP - 917

JO - Arteriosclerosis Thrombosis and Vascular Biology

JF - Arteriosclerosis Thrombosis and Vascular Biology

ER -

Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

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