Effects of cardiac structural remodelling during heart failure on cardiac excitation - Insights from a heterogeneous 3D model of the rabbit atria

Petros Kottas, Michael A. Colman, Robert S. Stephenson, Simon J. Castro, George Hart, Jonathan C. Jarvis, Mark Boyett, Henggui Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Heart failure is a leading cause of morbidity and mortality in the western world. One of the effects of heart failure is the structural remodelling of cardiac tissue, including tissue dilation and development of fibrosis. It is therefore important to study these changes and their effect on cardiac activity, in order to gain a better understanding of the underlying mechanisms in arrhythmogenesis, which will hopefully enable us to develop better treatments for heart failure. In this study we developed biophysically detailed models of the rabbit atria for normal and heart failure conditions. These models were used to study the effects of structural remodelling of heart failure on cardiac excitation wave conduction. Anatomical reconstructions of the control and heart failure hearts were based on contrast enhanced micro-CT imaging. Fibre orientation was extracted from the control and heart failure datasets. Effects of heart failure geometry on the activation pattern of atrial excitation waves were analyzed. It was found that atrial activation time increased from the control to the heart failure case in both isotropic and anisotropic conditions, which is attributed primarily to the dilation of tissue caused by heart failure.

Original languageEnglish
Title of host publicationComputing in Cardiology Conference 2015, CinC 2015
EditorsAlan Murray
PublisherIEEE Computer Society
Pages969-972
Number of pages4
ISBN (Electronic)9781509006854
DOIs
Publication statusPublished - 16 Feb 2015
Event42nd Computing in Cardiology Conference, CinC 2015 - Nice, France
Duration: 6 Sep 20159 Sep 2015

Publication series

NameComputing in Cardiology
Volume42
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Conference

Conference42nd Computing in Cardiology Conference, CinC 2015
Country/TerritoryFrance
CityNice
Period6/09/159/09/15

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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