Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure

Julian Vaile; Saqib Chowdhary; Faizel Osman; Hamish Ross; Janine Fletcher; William Littler; John Coote; Jonathan Townend

doi:10.1042/CS20010069

Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure

Julian Vaile, Saqib Chowdhary, Faizel Osman, Hamish Ross, Janine Fletcher, William Littler, John Coote, Jonathan Townend

Birmingham Medical School

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

The objective of the present study was to determine the autonomic effects of angiotensin II (AT(1)) receptor blocker therapy in heart failure. In a randomized double-blind cross-over study, we compared the effects of candesartan and placebo on baroreflex sensitivity and on heart rate variability at rest, during stress and during 24 h monitoring. Acute effects were assessed 4 h after oral candesartan (8 mg) and chronic effects after 4 weeks of treatment (dose titrated to 16 mg daily). The study group comprised 21 patients with heart failure [mean (S.E.M.) ejection fraction 33% (1%)], in the absence of angiotensin-converting enzyme (ACE) inhibitor therapy. We found that acute candesartan was not different from placebo in its effects on blood pressure or mean RR interval. Chronic candesartan significantly reduced blood pressure [placebo, 137 (3)/82 (3) mmHg; candesartan, 121 (4)/75 (2) mmHg; P

Original language	English
Pages (from-to)	559-566
Number of pages	8
Journal	Clinical Science
Volume	101
Issue number	6
DOIs	https://doi.org/10.1042/CS20010069
Publication status	Published - 1 Dec 2001

Keywords

heart rate
baroreflex sensitivity
vagus nerve
heart rate variability
angiotensin
heart failure

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10.1042/CS20010069

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title = "Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure",

abstract = "The objective of the present study was to determine the autonomic effects of angiotensin II (AT(1)) receptor blocker therapy in heart failure. In a randomized double-blind cross-over study, we compared the effects of candesartan and placebo on baroreflex sensitivity and on heart rate variability at rest, during stress and during 24 h monitoring. Acute effects were assessed 4 h after oral candesartan (8 mg) and chronic effects after 4 weeks of treatment (dose titrated to 16 mg daily). The study group comprised 21 patients with heart failure [mean (S.E.M.) ejection fraction 33% (1%)], in the absence of angiotensin-converting enzyme (ACE) inhibitor therapy. We found that acute candesartan was not different from placebo in its effects on blood pressure or mean RR interval. Chronic candesartan significantly reduced blood pressure [placebo, 137 (3)/82 (3) mmHg; candesartan, 121 (4)/75 (2) mmHg; P",

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AU - Vaile, Julian

AU - Chowdhary, Saqib

AU - Osman, Faizel

AU - Ross, Hamish

AU - Fletcher, Janine

AU - Littler, William

AU - Coote, John

AU - Townend, Jonathan

PY - 2001/12/1

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KW - heart rate

KW - baroreflex sensitivity

KW - vagus nerve

KW - heart rate variability

KW - angiotensin

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Effects of angiotensin II (AT1) receptor blockade on cardiac vagal control in heart failure

Abstract

Keywords

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