Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments

Yue Zhang; Alison J. Davenport; Bernard Burke; Nina Vyas; Owen Addison

doi:10.1021/acsbiomaterials.7b00882

Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments

Yue Zhang, Alison J. Davenport, Bernard Burke, Nina Vyas, Owen Addison

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Abstract

The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and reactive oxygen species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially pure (CP) Ti, Zr, and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility. Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.

Original language	English
Pages (from-to)	1103-1111
Journal	ACS Biomaterial Science and Engineering
Volume	4
Issue number	3
Early online date	19 Feb 2018
DOIs	https://doi.org/10.1021/acsbiomaterials.7b00882
Publication status	Published - 12 Mar 2018

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10.1021/acsbiomaterials.7b00882

The effect of Zr addition on the corrosion of Ti in acidic and reactive oxygen species (ROS)-containing environments AAM
Final Version of record available at: http://dx.doi.org/10.1021/acsbiomaterials.7b00882 and is published as above Checked 27/3/2018
Accepted author manuscript, 1.71 MBLicence: None: All rights reserved

http://pubs.acs.org/doi/10.1021/acsbiomaterials.7b00882

Modification of the inflammatory response in peri-implant sites by titanium ions and debris
Addison, O. (Principal Investigator), Chapple, I. (Co-Investigator) & Cooper, P. (Co-Investigator)
NIHR
1/03/11 → 29/02/16
Project: Other Government Departments

Cite this

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title = "Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments",

abstract = "The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and reactive oxygen species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially pure (CP) Ti, Zr, and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility. Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.",

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AU - Vyas, Nina

AU - Addison, Owen

PY - 2018/3/12

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AB - The effect of systematic Zr additions on the corrosion behavior of Ti was studied in both acidic and reactive oxygen species (ROS) containing environments, including macrophage cell culture, simulating inflammation associated with metallic implants. Electrochemical measurements on commercially pure (CP) Ti, Zr, and TiZr alloys showed that increasing Zr additions progressively enhanced Ti passivity in both acidic (HCl) and oxidative (H2O2) environments. However, a Ti50Zr alloy was found with increased pitting susceptibility. Corrosion was also evaluated using mass-spectrometry to determine metal ion release following exposure of the alloys to THP-1 macrophage cell cultures, transformed into either their M1 (inflammatory states) or M2a (tissue repair states) phenotypes. The magnitude of ion release was reduced with increasing Zr contents, consistent with electrochemical observations. Nevertheless, optimized Zr content in Ti should balance both passivity and pitting resistance.

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Effect of Zr Addition on the Corrosion of Ti in Acidic and Reactive Oxygen Species (ROS)-Containing Environments

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Modification of the inflammatory response in peri-implant sites by titanium ions and debris

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