Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

T J Mitchell; J M Ketley; S C Haslam; J Stephen; D W Burdon; D C Candy; R Daniel

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

T J Mitchell
, J M Ketley
, S C Haslam
, J Stephen
, D W Burdon
, D C Candy
, R Daniel

Microbes, Infection and Microbiomes

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

Original language	English
Pages (from-to)	78-85
Number of pages	8
Journal	Gut
Volume	27
Issue number	1
Publication status	Published - Jan 1986

Keywords

Animals
Bacterial Toxins
Clostridium
Colon
Cytotoxins
Dose-Response Relationship, Drug
Enterotoxins
Ileum
Male
Permeability
Rabbits
Time Factors

Cite this

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title = "Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon",

abstract = "The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.",

keywords = "Animals, Bacterial Toxins, Clostridium, Colon, Cytotoxins, Dose-Response Relationship, Drug, Enterotoxins, Ileum, Male, Permeability, Rabbits, Time Factors",

author = "Mitchell, \{T J\} and Ketley, \{J M\} and Haslam, \{S C\} and J Stephen and Burdon, \{D W\} and Candy, \{D C\} and R Daniel",

year = "1986",

month = jan,

language = "English",

volume = "27",

pages = "78--85",

journal = "Gut",

issn = "0017-5749",

publisher = "BMJ Publishing Group",

number = "1",

}

TY - JOUR

T1 - Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

AU - Mitchell, T J

AU - Ketley, J M

AU - Haslam, S C

AU - Stephen, J

AU - Burdon, D W

AU - Candy, D C

AU - Daniel, R

PY - 1986/1

Y1 - 1986/1

N2 - The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

AB - The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.

KW - Animals

KW - Bacterial Toxins

KW - Clostridium

KW - Colon

KW - Cytotoxins

KW - Dose-Response Relationship, Drug

KW - Enterotoxins

KW - Ileum

KW - Male

KW - Permeability

KW - Rabbits

KW - Time Factors

M3 - Article

C2 - 3949240

SN - 0017-5749

VL - 27

SP - 78

EP - 85

JO - Gut

JF - Gut

IS - 1

ER -

Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon

Abstract

Keywords

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