Abstract
The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.
| Original language | English |
|---|---|
| Pages (from-to) | 78-85 |
| Number of pages | 8 |
| Journal | Gut |
| Volume | 27 |
| Issue number | 1 |
| Publication status | Published - Jan 1986 |
Keywords
- Animals
- Bacterial Toxins
- Clostridium
- Colon
- Cytotoxins
- Dose-Response Relationship, Drug
- Enterotoxins
- Ileum
- Male
- Permeability
- Rabbits
- Time Factors