Effect of the technique of photodynamic therapy against the main microorganisms responsible for periodontitis: a systematic review of in-vitro studies

Luciana Solera Sales, Marina Lins Miranda, Analu Barros de Oliveira, Tulio Morandin Ferrisse, Carla Raquel Fontana, Michael Milward, Fernanda Lourencao Brighenti

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective
The present study aimed to conduct a systematic review of the literature, to evaluate, in vitro, the effectiveness of the technique of photodynamic therapy against microorganisms associated with periodontal disease.

Design
This systematic review was carried out in accordance with the items on the PRISMA checklist and Cochrane guidelines. Only in vitro studies that evaluated the effect of the technique of antimicrobial photodynamic therapy on periodontopathogenic microorganisms were included.

Results
A total of 32 articles published between 2000 and 2021 were included for qualitative analysis. For microorganisms in suspension, 25 studies (78.12%) showed a reduction greater than or equal to 3 logs CFU/mL of species associated with periodontal disease. In biofilms, three studies (42.7%) showed a reduction greater than or equal to 3 logs CFU/mL.

Conclusions
The results showed that the technique of photodynamic therapy may be a promising alternative to conventional antimicrobial approaches for reducing bacteria closely associated with periodontal disease. Some parameters (pre-irradiation time, type of photosensitizer, standardization of light parameters) need to be better established before conducting clinical studies.
Original languageEnglish
Article number105425
Number of pages13
JournalArchives of Oral Biology
Volume138
Early online date25 Mar 2022
DOIs
Publication statusE-pub ahead of print - 25 Mar 2022

Bibliographical note

Funding Information:
This study was supported in part by the Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - Brasil (CAPES) - Finance Code 001, by the S?o Paulo Research Foundation (FAPESP) (grant 2019/08375-0, 2019/26066-4, 2020/07110-0, 2021/01191-0 and 2021/12931-5). CAPES and FAPESP had no involvement in: the study design; the collection, analysis and interpretation of data; the writing of the report; and the decision to submit the article for publication.

Funding Information:
This study was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 , by the São Paulo Research Foundation (FAPESP) (grant 2019/08375-0 , 2019/26066-4 , 2020/07110-0 , 2021/01191-0 and 2021/12931-5 ). CAPES and FAPESP had no involvement in: the study design; the collection, analysis and interpretation of data; the writing of the report; and the decision to submit the article for publication.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Microorganisms
  • Periodontal disease
  • Technique of photodynamic therapy

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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