Effect of repetitive transcranial magnetic stimulation combined with robot-assisted training on wrist muscle activation post-stroke

Kimberly J Miller, Alessio Gallina, Jason L Neva, Tanya D Ivanova, Nicholas J Snow, Noah M Ledwell, Zhen G Xiao, Carlo Menon, Lara A Boyd, S Jayne Garland

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
140 Downloads (Pure)

Abstract

OBJECTIVE: To compare the effects of active assisted wrist extension training, using a robotic exoskeleton (RW), with simultaneous 5 Hz (rTMS + RW) or Sham rTMS (Sham rTMS + RW) over the ipsilesional extensor carpi radialis motor cortical representation, on voluntary wrist muscle activation following stroke.

METHODS: The two training conditions were completed at least one week apart in 13 participants >1-year post-stroke. Voluntary wrist extensor muscle activation (motor unit (MU) recruitment thresholds and firing rate modulation in a ramp-hold handgrip task), ipsilesional corticospinal excitability (motor evoked potential [MEP] amplitude) and transcallosal inhibition were measured Pre- and Post-training.

RESULTS: For MUs active both Pre and Post training, greater reductions in recruitment thresholds were found Post rTMS + RW training (p = 0.0001) compared to Sham rTMS + RW (p = 0.16). MU firing rate modulation increased following both training conditions (p = 0.001). Ipsilesional MEPs were elicited Pre and Post in only 5/13 participants. No significant changes were seen in ipsilesional corticospinal excitability and transcallosal inhibition measures (p > 0.05).

CONCLUSIONS: Following a single rTMS + RW session in people >1-year post-stroke, changes were found in voluntary muscle activation of wrist extensor muscles. Alterations in ipsilesional corticospinal or interhemispheric excitability were not detected.

SIGNIFICANCE: The effects of rTMS + RW on muscle activation warrant further investigation as post-stroke rehabilitation strategy.

Original languageEnglish
Pages (from-to)1271-1279
Number of pages9
JournalClinical Neurophysiology
Volume130
Issue number8
Early online date20 May 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • Motor unit
  • Rehabilitation
  • Repetitive Transcranial Magnetic Stimulation
  • Robotic exoskeleton
  • Stroke
  • Upper extremity

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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