Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

P Roberts; P K Jeffery; T J Mitchell; P W Andrew; G J Boulnois; C Feldman; P J Cole; R Wilson

Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

P Roberts, P K Jeffery, T J Mitchell, P W Andrew, G J Boulnois, C Feldman, P J Cole, R Wilson

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Immunization with Freund's adjuvant and pneumolysin and stimulation with Freund's adjuvant alone both reduced the severity of the pneumonia caused by injections of bacteria into the apical lobe bronchi of rats. Neither protocol influenced the incidence of pneumococcal bacteremia. Illness sufficiently severe to require sacrifice was delayed from 2.8 days in nonimmunized animals to 5.7 days in those immunized with Freund's adjuvant and pneumolysin (P < 0.05) and 4.5 days in those stimulated with Freund's adjuvant alone (P, not significant).

Original language	English
Pages (from-to)	4969-72
Number of pages	4
Journal	Infection and Immunity
Volume	60
Issue number	11
Publication status	Published - Nov 1992

Keywords

Adjuvants, Immunologic
Animals
Bacterial Proteins
Immunization
Pneumonia, Pneumococcal
Rats
Rats, Wistar
Streptolysins

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title = "Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo",

abstract = "Immunization with Freund's adjuvant and pneumolysin and stimulation with Freund's adjuvant alone both reduced the severity of the pneumonia caused by injections of bacteria into the apical lobe bronchi of rats. Neither protocol influenced the incidence of pneumococcal bacteremia. Illness sufficiently severe to require sacrifice was delayed from 2.8 days in nonimmunized animals to 5.7 days in those immunized with Freund's adjuvant and pneumolysin (P < 0.05) and 4.5 days in those stimulated with Freund's adjuvant alone (P, not significant).",

keywords = "Adjuvants, Immunologic, Animals, Bacterial Proteins, Immunization, Pneumonia, Pneumococcal, Rats, Rats, Wistar, Streptolysins",

author = "P Roberts and Jeffery, {P K} and Mitchell, {T J} and Andrew, {P W} and Boulnois, {G J} and C Feldman and Cole, {P J} and R Wilson",

year = "1992",

month = nov,

language = "English",

volume = "60",

pages = "4969--72",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

AU - Roberts, P

AU - Jeffery, P K

AU - Mitchell, T J

AU - Andrew, P W

AU - Boulnois, G J

AU - Feldman, C

AU - Cole, P J

AU - Wilson, R

PY - 1992/11

Y1 - 1992/11

N2 - Immunization with Freund's adjuvant and pneumolysin and stimulation with Freund's adjuvant alone both reduced the severity of the pneumonia caused by injections of bacteria into the apical lobe bronchi of rats. Neither protocol influenced the incidence of pneumococcal bacteremia. Illness sufficiently severe to require sacrifice was delayed from 2.8 days in nonimmunized animals to 5.7 days in those immunized with Freund's adjuvant and pneumolysin (P < 0.05) and 4.5 days in those stimulated with Freund's adjuvant alone (P, not significant).

AB - Immunization with Freund's adjuvant and pneumolysin and stimulation with Freund's adjuvant alone both reduced the severity of the pneumonia caused by injections of bacteria into the apical lobe bronchi of rats. Neither protocol influenced the incidence of pneumococcal bacteremia. Illness sufficiently severe to require sacrifice was delayed from 2.8 days in nonimmunized animals to 5.7 days in those immunized with Freund's adjuvant and pneumolysin (P < 0.05) and 4.5 days in those stimulated with Freund's adjuvant alone (P, not significant).

KW - Adjuvants, Immunologic

KW - Animals

KW - Bacterial Proteins

KW - Immunization

KW - Pneumonia, Pneumococcal

KW - Rats

KW - Rats, Wistar

KW - Streptolysins

M3 - Article

C2 - 1399007

SN - 0019-9567

VL - 60

SP - 4969

EP - 4972

JO - Infection and Immunity

JF - Infection and Immunity

IS - 11

ER -

Effect of immunization with Freund's adjuvant and pneumolysin on histologic features of pneumococcal infection in the rat lung in vivo

Abstract

Keywords

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