TY - JOUR
T1 - Effect of catechol derivatives on cell growth and lipoxygenase activity
AU - Simpson, Julie
AU - Forrester, R
AU - Tisdale, MJ
AU - Billington, DC
AU - Rathbone, DL
PY - 2003/8/4
Y1 - 2003/8/4
N2 - Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).
AB - Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).
UR - http://www.scopus.com/inward/record.url?scp=0037972031&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00528-6
DO - 10.1016/S0960-894X(03)00528-6
M3 - Article
C2 - 12852938
VL - 13
SP - 2435
EP - 2439
JO - Bioorganic & Medicinal Chemistry Letters
JF - Bioorganic & Medicinal Chemistry Letters
IS - 15
ER -