Effect of catechol derivatives on cell growth and lipoxygenase activity

Julie Simpson, R Forrester, MJ Tisdale, DC Billington, DL Rathbone

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Derivatives of salicylic acid have been synthesized as potential lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).
    Original languageEnglish
    Pages (from-to)2435-2439
    Number of pages5
    JournalBioorganic & Medicinal Chemistry Letters
    Issue number15
    Publication statusPublished - 4 Aug 2003


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