Economic evaluation of interventions in Parkinson's disease: a systematic literature review

Nafsika Afentou, Johan Jarl, Ulf-G Gerdtham, Sanjib Saha

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
147 Downloads (Pure)


Background: Parkinson's disease (PD) management comprises of drug treatments, surgery and physical activity/occupational therapies to relieve PD's symptoms. The aim of this study is twofold; firstly, to appraise recent economic evaluation studies on PD management in order to update the existing knowledge and, secondly, to facilitate decision making on PD management by assessing the cost‐effectiveness of all types of PD interventions.

Methods: A systematic search for studies published between 2010 and 2018 was conducted. The inclusion and exclusion of the articles were based on criteria relevant to Population, Intervention, Comparison, Outcomes and Study design (PICO). The reporting quality of the articles was assessed according to Consolidated Health Economic Evaluation Reporting Standards.

Results: Twenty eight articles were included, 10 of which were evaluations of drug treatments, 10 deep brain stimulation (DBS) and 8 physical/occupational therapies. Among early‐stage treatments, Ti Ji dominated all physical activity interventions, however, its cost‐effectiveness should be further explored in relation to its duration, intensity, and frequency. Multidisciplinary interventions of joint medical and non‐medical therapies provided slightly better health outcomes for the same costs. In advanced PD patients, adjunct drug treatments could become more cost‐effective if introduced during early PD and, although DBS was more cost‐effective than adjunct drug therapies, the results were time‐bound.

Conclusion: Conditionally, certain PD interventions are cost‐effective. However, PD progression differs in each patient, thus the cost‐effectiveness of individually‐tailored combinations of interventions, which could provide more time in less severe disease states and improve patients’ and caregivers’ quality of life, should be further explored.
Original languageEnglish
Pages (from-to)282-290
JournalMovement Disorders Clinical Practice
Issue number4
Early online date12 Mar 2019
Publication statusPublished - 22 Apr 2019


  • Parkinson's disease
  • Parkinson's disease management
  • cost-effectiveness
  • economic evaluations


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