Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts

James P. C. Coverdale; Carlos Sanchez-Cano; Guy J. Clarkson; Rina Soni; Martin Wills; Peter J. Sadler

doi:10.1002/chem.201500534

Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts

James P. C. Coverdale, Carlos Sanchez-Cano, Guy J. Clarkson, Rina Soni, Martin Wills, Peter J. Sadler

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type RuII catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.

Original language	English
Pages (from-to)	8043-8046
Journal	Chemistry - A European Journal
Volume	21
Issue number	22
DOIs	https://doi.org/10.1002/chem.201500534
Publication status	Published - 8 Apr 2015

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10.1002/chem.201500534

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title = "Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts",

abstract = "Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type RuII catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.",

author = "Coverdale, \{James P. C.\} and Carlos Sanchez-Cano and Clarkson, \{Guy J.\} and Rina Soni and Martin Wills and Sadler, \{Peter J.\}",

year = "2015",

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doi = "10.1002/chem.201500534",

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volume = "21",

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journal = "Chemistry - A European Journal",

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T1 - Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts

AU - Coverdale, James P. C.

AU - Sanchez-Cano, Carlos

AU - Clarkson, Guy J.

AU - Soni, Rina

AU - Wills, Martin

AU - Sadler, Peter J.

PY - 2015/4/8

Y1 - 2015/4/8

N2 - Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type RuII catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.

AB - Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori-type RuII catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X-ray crystal structures of the 16-electron OsII catalysts are almost identical to those of RuII. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The OsII catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.

U2 - 10.1002/chem.201500534

DO - 10.1002/chem.201500534

M3 - Article

SN - 0947-6539

VL - 21

SP - 8043

EP - 8046

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 22

ER -

Easy To Synthesize, Robust Organo-osmium Asymmetric Transfer Hydrogenation Catalysts

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