Abstract
Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neutrophils gradually lose the anti-apoptotic protein Mcl-1 and Bax translocates and inserts into the mitochondrial membrane. However, other reports show that caspase 8 is required for neutrophil apoptosis, suggesting the involvement of DR (death receptor) signalling. As DR ligation is not required for neutrophil apoptosis, this raises the intriguing possibility that activation of caspase 8 during neutrophil apoptosis occurs via a novel mechanism. in the present paper, we discuss the current evidence for mechanisms occurring in neutrophil apoptosis, which could trigger DR signalling in the absence of DR ligation.
Original language | English |
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Pages (from-to) | 461-4 |
Number of pages | 4 |
Journal | Biochemical Society Transactions |
Volume | 32 |
Issue number | Pt 3 |
DOIs | |
Publication status | Published - 1 Jan 2004 |
Keywords
- inflammation
- apoptosis
- neutrophil
- caspase 8
- Bcl-2
- lipid raft
- death receptor