Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis

D M Carruthers; H P Arrol; P A Bacon; Stephen Young; Stephen Young

doi:10.1002/1529-0131(200006)43:6<1257::AID-ANR8>3.0.CO;2-Q

Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis

D M Carruthers
, H P Arrol
, P A Bacon
, Stephen Young
, Stephen Young

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Peripheral blood (PB) T cells from rheumatoid arthritis (RA) patients proliferate poorly to mitogen, a change that is related to decreased intracellular Ca2+ ([Ca2+]i) signaling after T cell receptor (TCR) stimulation. We hypothesized that this was, in part, due to the effect of mediators of inflammation and predicted that greater changes in [Ca2+]i signaling would be seen in synovial fluid (SF) T cells. We also examined the mechanisms underlying the altered [Ca2+]i signals.

Original language	English
Pages (from-to)	1257-65
Number of pages	9
Journal	Arthritis & Rheumatism
Volume	43
Issue number	6
DOIs	https://doi.org/10.1002/1529-0131(200006)43:6<1257::AID-ANR8>3.0.CO;2-Q
Publication status	Published - Jun 2000

Keywords

Reference Values
Calcium
Endoplasmic Reticulum
Humans
Intracellular Membranes
Arthritis, Rheumatoid
Enzyme Inhibitors
Thapsigargin
Inositol 1,4,5-Trisphosphate
Ionomycin
Chronic Disease
Synovial Fluid
Organelles
Ionophores
Calcium Signaling
T-Lymphocytes

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10.1002/1529-0131(200006)43:6<1257::AID-ANR8>3.0.CO;2-Q

Cite this

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title = "Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis",

abstract = "Peripheral blood (PB) T cells from rheumatoid arthritis (RA) patients proliferate poorly to mitogen, a change that is related to decreased intracellular Ca2+ ([Ca2+]i) signaling after T cell receptor (TCR) stimulation. We hypothesized that this was, in part, due to the effect of mediators of inflammation and predicted that greater changes in [Ca2+]i signaling would be seen in synovial fluid (SF) T cells. We also examined the mechanisms underlying the altered [Ca2+]i signals.",

keywords = "Reference Values, Calcium, Endoplasmic Reticulum, Humans, Intracellular Membranes, Arthritis, Rheumatoid, Enzyme Inhibitors, Thapsigargin, Inositol 1,4,5-Trisphosphate, Ionomycin, Chronic Disease, Synovial Fluid, Organelles, Ionophores, Calcium Signaling, T-Lymphocytes",

author = "Carruthers, \{D M\} and Arrol, \{H P\} and Bacon, \{P A\} and Stephen Young and Stephen Young",

year = "2000",

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doi = "10.1002/1529-0131(200006)43:6<1257::AID-ANR8>3.0.CO;2-Q",

language = "English",

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journal = "Arthritis \& Rheumatism",

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T1 - Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis

AU - Carruthers, D M

AU - Arrol, H P

AU - Bacon, P A

AU - Young, Stephen

PY - 2000/6

Y1 - 2000/6

N2 - Peripheral blood (PB) T cells from rheumatoid arthritis (RA) patients proliferate poorly to mitogen, a change that is related to decreased intracellular Ca2+ ([Ca2+]i) signaling after T cell receptor (TCR) stimulation. We hypothesized that this was, in part, due to the effect of mediators of inflammation and predicted that greater changes in [Ca2+]i signaling would be seen in synovial fluid (SF) T cells. We also examined the mechanisms underlying the altered [Ca2+]i signals.

AB - Peripheral blood (PB) T cells from rheumatoid arthritis (RA) patients proliferate poorly to mitogen, a change that is related to decreased intracellular Ca2+ ([Ca2+]i) signaling after T cell receptor (TCR) stimulation. We hypothesized that this was, in part, due to the effect of mediators of inflammation and predicted that greater changes in [Ca2+]i signaling would be seen in synovial fluid (SF) T cells. We also examined the mechanisms underlying the altered [Ca2+]i signals.

KW - Reference Values

KW - Calcium

KW - Endoplasmic Reticulum

KW - Humans

KW - Intracellular Membranes

KW - Arthritis, Rheumatoid

KW - Enzyme Inhibitors

KW - Thapsigargin

KW - Inositol 1,4,5-Trisphosphate

KW - Ionomycin

KW - Chronic Disease

KW - Synovial Fluid

KW - Organelles

KW - Ionophores

KW - Calcium Signaling

KW - T-Lymphocytes

U2 - 10.1002/1529-0131(200006)43:6<1257::AID-ANR8>3.0.CO;2-Q

DO - 10.1002/1529-0131(200006)43:6<1257::AID-ANR8>3.0.CO;2-Q

M3 - Article

C2 - 10857784

SN - 0004-3591

VL - 43

SP - 1257

EP - 1265

JO - Arthritis & Rheumatism

JF - Arthritis & Rheumatism

IS - 6

ER -

Dysregulated intracellular Ca2+ stores and Ca2+ signaling in synovial fluid T lymphocytes from patients with chronic inflammatory arthritis

Abstract

Keywords

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