Abstract
The design and development of controlled release systems of molecules of interest (nutrients, flavors, and drugs) have attracted significant attention over several years. Herein, we report a formulation of dual temperature and electro responsive κ- and ι-carrageenan based hydrogel for efficient food material and drug delivery. The microstructure and the thermal behavior of the hydrogel were characterized. The in-vitro drug release from the hydrogel was also studied. Using this carrageenan-based formulation and folic acid as the drug model, a high drug loading, and a sustained release because of either electric field or temperature were observed. In principle, the proposed formulation does not rely on 3D printing to perform its function; however, it adds to the feedstocks for 3D printing in the food and pharmaceutical industries. For the future, this could allow potentially more complex smart structures to be created from this material, further tuning release behavior.
Original language | English |
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Pages (from-to) | 370-379 |
Number of pages | 10 |
Journal | International Journal of Biological Macromolecules |
Volume | 189 |
Early online date | 24 Aug 2021 |
DOIs | |
Publication status | Published - 31 Oct 2021 |
Bibliographical note
Funding Information:This work was supported by the Engineering and Physical Sciences Research Council [grant number EP/N024818/1].
Keywords
- 3D printing
- Drug delivery
- Polyelectrolyte
- Responsive biopolymer
- Smart hydrogels
- Magnetic Resonance Spectroscopy
- Time Factors
- Calorimetry, Differential Scanning
- Folic Acid/pharmacology
- Printing, Three-Dimensional
- Carrageenan/chemistry
ASJC Scopus subject areas
- General Energy
- Economics and Econometrics
- Molecular Biology
- Structural Biology
- Biochemistry