Dual role for phenylalanine 178 during catalysis by aristolochene synthase

S Forcat; Rudolf Allemann

doi:10.1039/b407932a

Dual role for phenylalanine 178 during catalysis by aristolochene synthase

S Forcat, Rudolf Allemann

Chemistry

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24 Citations (Scopus)

Abstract

A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha- and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

Original language	English
Pages (from-to)	2094-2095
Number of pages	2
Journal	Chemical Communications
Issue number	18
DOIs	https://doi.org/10.1039/b407932a
Publication status	Published - 1 Jan 2004

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title = "Dual role for phenylalanine 178 during catalysis by aristolochene synthase",

abstract = "A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha- and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.",

author = "S Forcat and Rudolf Allemann",

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N2 - A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha- and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

AB - A mutant of aristolochene synthase, in which Phe 178 was replaced by Val, produced significant amounts of alpha- and beta-farnesene as well as alpha and beta-selinene and selina-4,11-diene, suggesting that Phe 178 is involved in the stabilisation of transition states preceding germacrene A and following eudesmane cation.

U2 - 10.1039/b407932a

DO - 10.1039/b407932a

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SP - 2094

EP - 2095

JO - Chemical Communications

JF - Chemical Communications

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ER -

Dual role for phenylalanine 178 during catalysis by aristolochene synthase

Abstract

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