Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing

HYE Chan, Saverio Brogna, CJ O'Kane

Research output: Contribution to journalArticle

19 Citations (Scopus)


The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe(+) is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected.
Original languageEnglish
Pages (from-to)1409-1419
Number of pages11
JournalMolecular Biology of the Cell
Issue number5
Publication statusPublished - 1 Jan 2001


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