Doxycycline and Autogenous Bone in Repair of Critical-Size Defects

Ribamar Lazanha Lucateli; Marina Angélica Marciano; Sabrina Ferreira; Idelmo Rangel Garcia Júnior; Josette Camilleri; Ronaldo Célio Mariano

doi:10.1097/ID.0000000000000783

Doxycycline and Autogenous Bone in Repair of Critical-Size Defects

Ribamar Lazanha Lucateli, Marina Angélica Marciano, Sabrina Ferreira, Idelmo Rangel Garcia Júnior, Josette Camilleri, Ronaldo Célio Mariano

Dentistry

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Abstract

PURPOSE: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated.

MATERIALS AND METHODS: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P < 0.05).

RESULTS: The results showed that new bone formation was limited to the margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone formation (38.59% and 47.86%, respectively), with statistical difference in comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT (15.89%) at 8 weeks (P < 0.05).

CONCLUSIONS: The association of 10% DOX with autogenous bone significantly improved bone healing in critical-size defects.

Original language	English
Journal	Implant dentistry
Early online date	1 Jun 2018
DOIs	https://doi.org/10.1097/ID.0000000000000783
Publication status	E-pub ahead of print - 1 Jun 2018

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Journal Article

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10.1097/ID.0000000000000783

Doxycycline and autogenous bone in repair of critical-size defects AAM
This is the accepted manuscript version. The final version of record was published as: Lucateli, Ribamar Lazanha, et al. "Doxycycline and Autogenous Bone in Repair of Critical-Size Defects." Implant dentistry (2018).
Accepted author manuscript, 242 KBLicence: None: All rights reserved

Cite this

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title = "Doxycycline and Autogenous Bone in Repair of Critical-Size Defects",

abstract = "PURPOSE: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated.MATERIALS AND METHODS: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P < 0.05).RESULTS: The results showed that new bone formation was limited to the margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone formation (38.59% and 47.86%, respectively), with statistical difference in comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT (15.89%) at 8 weeks (P < 0.05).CONCLUSIONS: The association of 10% DOX with autogenous bone significantly improved bone healing in critical-size defects.",

keywords = "Journal Article",

author = "Lucateli, {Ribamar Lazanha} and Marciano, {Marina Ang{\'e}lica} and Sabrina Ferreira and {Garcia J{\'u}nior}, {Idelmo Rangel} and Josette Camilleri and Mariano, {Ronaldo C{\'e}lio}",

year = "2018",

month = jun,

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doi = "10.1097/ID.0000000000000783",

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T1 - Doxycycline and Autogenous Bone in Repair of Critical-Size Defects

AU - Lucateli, Ribamar Lazanha

AU - Marciano, Marina Angélica

AU - Ferreira, Sabrina

AU - Garcia Júnior, Idelmo Rangel

AU - Camilleri, Josette

AU - Mariano, Ronaldo Célio

PY - 2018/6/1

Y1 - 2018/6/1

N2 - PURPOSE: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated.MATERIALS AND METHODS: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P < 0.05).RESULTS: The results showed that new bone formation was limited to the margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone formation (38.59% and 47.86%, respectively), with statistical difference in comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT (15.89%) at 8 weeks (P < 0.05).CONCLUSIONS: The association of 10% DOX with autogenous bone significantly improved bone healing in critical-size defects.

AB - PURPOSE: The association of doxycycline (DOX) and autogenous bone on repair of critical-size defects was evaluated.MATERIALS AND METHODS: Fifty albino rats were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with: control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was performed to assess the percentage of new bone in the defect area. Statistical analysis of the results was performed using analysis of variance and the Tukey test (P < 0.05).RESULTS: The results showed that new bone formation was limited to the margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone formation (38.59% and 47.86%, respectively), with statistical difference in comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT (15.89%) at 8 weeks (P < 0.05).CONCLUSIONS: The association of 10% DOX with autogenous bone significantly improved bone healing in critical-size defects.

KW - Journal Article

U2 - 10.1097/ID.0000000000000783

DO - 10.1097/ID.0000000000000783

M3 - Article

C2 - 29864050

SN - 1056-6163

JO - Implant dentistry

JF - Implant dentistry

ER -

Doxycycline and Autogenous Bone in Repair of Critical-Size Defects

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