[Dose-response relationship between smoking status and carotid atherosclerosis].

Chao qiang Jiang*, Lin Xu, Jie ming Lin, Tai hing Lam, Wei sen Zhang, Bin Liu, Ya li Jin, Kar keung Cheng, Thomas G. Neil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


To examine the dose-response relationship of smoking status with carotid atherosclerosis in 959 relatively healthy Chinese men. 959 older Chinese men were selected from Guangzhou Biobank Cohort Study (GBCS) on cardiovascular disease. Personal histories were collected and fasting plasma glucose and lipids, blood pressure, and common carotid artery intima-median thickness (CCA-IMT) were measured. (1) Composition of the cases: 39.1% were non-smokers, 25.7% were former smokers and 35.2% were current smokers. The mean (95% confidence interval) carotid IMT was 0.78 (0.77 - 0.79) mm. 18.4% of the subjects had carotid IMT equal to or thicker than 1.0 mm while 34.1% had carotid plaque. (2) After adjusting for age, sex, physical activity, body mass index, fasting glucose, triglyceride, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, compared to never smokers, current smokers had significantly increased risk for thicker IMT and carotid plaque [odds ratio (OR) = 1.82, 95%CI: 1.30 - 2.55 and OR = 1.95, 95%CI: 1.38 - 2.75, respectively, all P < 0.001]. The risk for thicker IMT and carotid plaque increased with the increasing amount (cigarettes/day) and duration of smoking (years) as well with cigarette pack-years (P for trend all ≤ 0.01). An elevated risk with a clear dose-response relationship was found between cigarette smoking and carotid atherosclerosis. Quitting smoking or reducing the amount of smoking may lower the risk of atherosclerosis, preventing and controlling the occurrence of cardiovascular diseases, and reducing the related cardiovascular mortalities.

Original languageEnglish
Pages (from-to)983-987
Number of pages5
JournalZhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
Issue number9
Publication statusPublished - 1 Sept 2010

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of '[Dose-response relationship between smoking status and carotid atherosclerosis].'. Together they form a unique fingerprint.

Cite this