Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils

Riana Cockeran; Annette J Theron; Charles Feldman; Timothy J Mitchell; Ronald Anderson

doi:10.1128/IAI.72.7.4327-4329.2004

Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils

Riana Cockeran, Annette J Theron, Charles Feldman, Timothy J Mitchell, Ronald Anderson

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Pneumolysin (4.18 ng/ml)-mediated influx of Ca(2+) and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

Original language	English
Pages (from-to)	4327-9
Number of pages	3
Journal	Infection and Immunity
Volume	72
Issue number	7
DOIs	https://doi.org/10.1128/IAI.72.7.4327-4329.2004
Publication status	Published - Jul 2004

Keywords

Bacterial Proteins
Calcium
Docosahexaenoic Acids
Eicosapentaenoic Acid
Humans
Inflammation
Neutrophils
Oxidants
Streptolysins

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10.1128/IAI.72.7.4327-4329.2004

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title = "Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils",

abstract = "Pneumolysin (4.18 ng/ml)-mediated influx of Ca(2+) and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.",

keywords = "Bacterial Proteins, Calcium, Docosahexaenoic Acids, Eicosapentaenoic Acid, Humans, Inflammation, Neutrophils, Oxidants, Streptolysins",

author = "Riana Cockeran and Theron, {Annette J} and Charles Feldman and Mitchell, {Timothy J} and Ronald Anderson",

year = "2004",

month = jul,

doi = "10.1128/IAI.72.7.4327-4329.2004",

language = "English",

volume = "72",

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journal = "Infection and Immunity",

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TY - JOUR

T1 - Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils

AU - Cockeran, Riana

AU - Theron, Annette J

AU - Feldman, Charles

AU - Mitchell, Timothy J

AU - Anderson, Ronald

PY - 2004/7

Y1 - 2004/7

N2 - Pneumolysin (4.18 ng/ml)-mediated influx of Ca(2+) and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

AB - Pneumolysin (4.18 ng/ml)-mediated influx of Ca(2+) and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 microg/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

KW - Bacterial Proteins

KW - Calcium

KW - Docosahexaenoic Acids

KW - Eicosapentaenoic Acid

KW - Humans

KW - Inflammation

KW - Neutrophils

KW - Oxidants

KW - Streptolysins

U2 - 10.1128/IAI.72.7.4327-4329.2004

DO - 10.1128/IAI.72.7.4327-4329.2004

M3 - Article

C2 - 15213185

SN - 0019-9567

VL - 72

SP - 4327

EP - 4329

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -

Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils

Abstract

Keywords

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