Abstract
DNA repair pathways can enable tumour cells to survive DNA damage that is induced by chemotherapeutic treatments; therefore, inhibitors of specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. There is evidence that drugs that inhibit one of these pathways in such tumours could prove useful as single-agent therapies, with the potential advantage that this approach could be selective for tumour cells and have fewer side effects.
| Original language | English |
|---|---|
| Pages (from-to) | 193-204 |
| Number of pages | 12 |
| Journal | Nature Reviews Cancer |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Mar 2008 |
Access to Document
- Helleday_2008_NatureReviewsCancer
The definitive, peer-reviewed and edited version of this article is published in Nature Reviews Science, volume 8, issue 3, 2008 [http://dx.doi.org/10.1038/nrc2342]"