DNA-polymer conjugates via the graft-through polymerisation of native DNA in water

Lucy A Arkinstall; Jonathan T Husband; Thomas R Wilks; Jeffrey C Foster; Rachel K O'Reilly

doi:10.1039/d0cc08008j

DNA-polymer conjugates via the graft-through polymerisation of native DNA in water

Lucy A Arkinstall
, Jonathan T Husband
, Thomas R Wilks
, Jeffrey C Foster
, Rachel K O'Reilly

Research output: Contribution to journal › Article › peer-review

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Abstract

The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

Original language	English
Pages (from-to)	5466-5469
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	57
Issue number	44
Early online date	24 Apr 2021
DOIs	https://doi.org/10.1039/d0cc08008j
Publication status	Published - 4 Jun 2021

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "DNA-polymer conjugates via the graft-through polymerisation of native DNA in water",

abstract = "The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.",

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AU - Arkinstall, Lucy A

AU - Husband, Jonathan T

AU - Wilks, Thomas R

AU - Foster, Jeffrey C

AU - O'Reilly, Rachel K

PY - 2021/6/4

Y1 - 2021/6/4

N2 - The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

AB - The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

UR - https://www.scopus.com/pages/publications/85107287271

U2 - 10.1039/d0cc08008j

DO - 10.1039/d0cc08008j

M3 - Article

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JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 44

ER -

DNA-polymer conjugates via the graft-through polymerisation of native DNA in water

Abstract

ASJC Scopus subject areas

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