DNA-polymer conjugates via the graft-through polymerisation of native DNA in water

Lucy A Arkinstall, Jonathan T Husband, Thomas R Wilks, Jeffrey C Foster, Rachel K O'Reilly

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Abstract

The direct, graft-through, ring-opening metathesis polymerisation (ROMP) of unprotected DNA macromonomers is reported. By tuning the polymerisation conditions, good control is achieved, enabling the rapid and efficient synthesis of DNA-containing bottlebrush copolymers, without the need for protection of the DNA bases.

Original languageEnglish
Pages (from-to)5466-5469
Number of pages4
JournalChemical communications (Cambridge, England)
Volume57
Issue number44
Early online date24 Apr 2021
DOIs
Publication statusPublished - 4 Jun 2021

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