DNA damage emergency: cellular garbage disposal to the rescue?

Helen Stone, Jo Morris

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


The proteasome is a cellular machine found in the cytosol, nucleus and on chromatin that performs much of the proteolysis in eukaryotic cells. Recent reports show it is enriched at sites of double-stranded DNA breaks (DSBs) in mammalian cells. What is it doing there? This review will address three possibilities suggested by recent reports: in degrading proteins after their ubiquitination at and eviction from chromatin; as a deubiquitinase, specific to the antagonism of ubiquitin conjugates generated as part of the signalling of a DSB; and as a functional component of DNA repair mechanism itself. These findings add complexity to the proteasome as a potential therapeutic target in cancer treatment.
Original languageEnglish
Pages (from-to)805-813
Publication statusPublished - 18 Mar 2013


  • DNA damage
  • cellular

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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