Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery

Ian Collins, Alan Jones

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)
122 Downloads (Pure)

Abstract

How can diversity-oriented strategies for chemical synthesis provide chemical tools to help shape our understanding of complex cancer pathways and progress anti-cancer drug discovery efforts? This review (surveying the literature from 2003 to the present) considers the applications of diversity-oriented synthesis (DOS), biology-oriented synthesis (BIOS) and associated strategies to cancer biology and drug discovery, summarising the syntheses of novel and often highly complex scaffolds from pluripotent or synthetically versatile building blocks. We highlight the role of diversity-oriented synthetic strategies in producing new chemical tools to interrogate cancer biology pathways through the assembly of relevant libraries and their application to phenotypic and biochemical screens. The use of diversity-oriented strategies to explore structure-activity relationships in more advanced drug discovery projects is discussed. We show how considering appropriate and variable focus in library design has provided a spectrum of DOS approaches relevant at all stages in anti-cancer drug discovery.

Original languageEnglish
Pages (from-to)17221-17255
Number of pages35
JournalMolecules
Volume19
Issue number11
DOIs
Publication statusPublished - 27 Oct 2014

Keywords

  • diversity-oriented synthesis (DOS)
  • biology-oriented synthesis (BIOS)
  • cancer
  • chemical tools
  • drug discovery

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