Diurnal variation of phenylalanine concentrations in tyrosinaemia type 1: should we be concerned?

A Daly; H Gokmen-Ozel; Anita MacDonald; MA Preece; Peter Davies; A Chakrapani; Patrick McKiernan

doi:10.1111/j.1365-277X.2011.01215.x

Diurnal variation of phenylalanine concentrations in tyrosinaemia type 1: should we be concerned?

A Daly, H Gokmen-Ozel, Anita MacDonald, MA Preece, Peter Davies, A Chakrapani, Patrick McKiernan

Birmingham Medical School

Research output: Contribution to journal › Article

15 Citations (Scopus)

Abstract

Background: Tyrosinaemia type 1 (HT1) is treated with a tyrosine and phenylalanine-restricted diet, amino acids free of phenylalanine and tyrosine, and nitisinone (NTBC). Treatment guidelines recommend plasma tyrosine between 200-400 μm and phenylalanine at least >30 μm. There is little information on the diurnal variation of plasma tyrosine or phenylalanine in HT1. Low plasma phenylalanine

Original language	English
Journal	Journal of Human Nutrition and Dietetics
DOIs	https://doi.org/10.1111/j.1365-277X.2011.01215.x
Publication status	Published - 15 Dec 2011

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10.1111/j.1365-277X.2011.01215.x

Cite this

@article{50242b2a6a544f948f02a754a2828050,

title = "Diurnal variation of phenylalanine concentrations in tyrosinaemia type 1: should we be concerned?",

abstract = "Background: Tyrosinaemia type 1 (HT1) is treated with a tyrosine and phenylalanine-restricted diet, amino acids free of phenylalanine and tyrosine, and nitisinone (NTBC). Treatment guidelines recommend plasma tyrosine between 200-400 μm and phenylalanine at least >30 μm. There is little information on the diurnal variation of plasma tyrosine or phenylalanine in HT1. Low plasma phenylalanine ",

author = "A Daly and H Gokmen-Ozel and Anita MacDonald and MA Preece and Peter Davies and A Chakrapani and Patrick McKiernan",

year = "2011",

month = dec,

day = "15",

doi = "10.1111/j.1365-277X.2011.01215.x",

language = "English",

journal = "Journal of Human Nutrition and Dietetics",