Dissecting the genetic heterogeneity of depression through age at onset

Robert A Power; Robert Keers; Mandy Y Ng; Amy W Butler; Rudolf Uher; Sarah Cohen-Woods; Marcus Ising; Nick Craddock; Michael J Owen; Ania Korszun; Lisa Jones; Ian Jones; Michael Gill; John P Rice; Joanna Hauser; Neven Henigsberg; Wolfgang Maier; Astrid Zobel; Ole Mors; Anna S Placentino; Marcella Rietschel; Daniel Souery; Dejan Kozel; Martin Preisig; Susanne Lucae; Elisabeth B Binder; Katherine J Aitchison; Federica Tozzi; Pierandrea Muglia; Gerome Breen; Ian W Craig; Anne E Farmer; Bertram Müller-Myhsok; Peter McGuffin; Cathryn M Lewis

doi:10.1002/ajmg.b.32093

Dissecting the genetic heterogeneity of depression through age at onset

Robert A Power, Robert Keers, Mandy Y Ng, Amy W Butler, Rudolf Uher, Sarah Cohen-Woods, Marcus Ising, Nick Craddock, Michael J Owen, Ania Korszun, Lisa Jones, Ian Jones, Michael Gill, John P Rice, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Astrid Zobel, Ole Mors, Anna S PlacentinoMarcella Rietschel, Daniel Souery, Dejan Kozel, Martin Preisig, Susanne Lucae, Elisabeth B Binder, Katherine J Aitchison, Federica Tozzi, Pierandrea Muglia, Gerome Breen, Ian W Craig, Anne E Farmer, Bertram Müller-Myhsok, Peter McGuffin, Cathryn M Lewis

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25 Citations (Scopus)

Abstract

Genome-wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub-types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome-wide association data on 2,746 cases and 1,594 screened controls from the RADIANT studies, with replication performed in 1,471 cases and 1,403 controls from two Munich studies. Three methods were used to analyze AAO: First a time-to-event analysis with controls censored, secondly comparing controls to case-subsets defined using AAO cut-offs, and lastly analyzing AAO as a quantitative trait. In the time-to-event analysis three SNPs reached suggestive significance (P

Original language	English
Pages (from-to)	859-68
Number of pages	10
Journal	American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Volume	159B
Issue number	7
DOIs	https://doi.org/10.1002/ajmg.b.32093
Publication status	Published - 2012

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Power, R. A., Keers, R., Ng, M. Y., Butler, A. W., Uher, R., Cohen-Woods, S., Ising, M., Craddock, N., Owen, M. J., Korszun, A., Jones, L., Jones, I., Gill, M., Rice, J. P., Hauser, J., Henigsberg, N., Maier, W., Zobel, A., Mors, O., ... Lewis, C. M. (2012). Dissecting the genetic heterogeneity of depression through age at onset. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , 159B(7), 859-68. https://doi.org/10.1002/ajmg.b.32093

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title = "Dissecting the genetic heterogeneity of depression through age at onset",

abstract = "Genome-wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub-types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome-wide association data on 2,746 cases and 1,594 screened controls from the RADIANT studies, with replication performed in 1,471 cases and 1,403 controls from two Munich studies. Three methods were used to analyze AAO: First a time-to-event analysis with controls censored, secondly comparing controls to case-subsets defined using AAO cut-offs, and lastly analyzing AAO as a quantitative trait. In the time-to-event analysis three SNPs reached suggestive significance (P ",

author = "Power, {Robert A} and Robert Keers and Ng, {Mandy Y} and Butler, {Amy W} and Rudolf Uher and Sarah Cohen-Woods and Marcus Ising and Nick Craddock and Owen, {Michael J} and Ania Korszun and Lisa Jones and Ian Jones and Michael Gill and Rice, {John P} and Joanna Hauser and Neven Henigsberg and Wolfgang Maier and Astrid Zobel and Ole Mors and Placentino, {Anna S} and Marcella Rietschel and Daniel Souery and Dejan Kozel and Martin Preisig and Susanne Lucae and Binder, {Elisabeth B} and Aitchison, {Katherine J} and Federica Tozzi and Pierandrea Muglia and Gerome Breen and Craig, {Ian W} and Farmer, {Anne E} and Bertram M{\"u}ller-Myhsok and Peter McGuffin and Lewis, {Cathryn M}",

note = "2012 Wiley Periodicals, Inc",

year = "2012",

doi = "10.1002/ajmg.b.32093",

language = "English",

volume = "159B",

pages = "859--68",

journal = "American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics ",

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Power, RA, Keers, R, Ng, MY, Butler, AW, Uher, R, Cohen-Woods, S, Ising, M, Craddock, N, Owen, MJ, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, JP, Hauser, J, Henigsberg, N, Maier, W, Zobel, A, Mors, O, Placentino, AS, Rietschel, M, Souery, D, Kozel, D, Preisig, M, Lucae, S, Binder, EB, Aitchison, KJ, Tozzi, F, Muglia, P, Breen, G, Craig, IW, Farmer, AE, Müller-Myhsok, B, McGuffin, P & Lewis, CM 2012, 'Dissecting the genetic heterogeneity of depression through age at onset', American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , vol. 159B, no. 7, pp. 859-68. https://doi.org/10.1002/ajmg.b.32093

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AU - Butler, Amy W

AU - Uher, Rudolf

AU - Cohen-Woods, Sarah

AU - Ising, Marcus

AU - Craddock, Nick

AU - Owen, Michael J

AU - Korszun, Ania

AU - Jones, Lisa

AU - Jones, Ian

AU - Gill, Michael

AU - Rice, John P

AU - Hauser, Joanna

AU - Henigsberg, Neven

AU - Maier, Wolfgang

AU - Zobel, Astrid

AU - Mors, Ole

AU - Placentino, Anna S

AU - Rietschel, Marcella

AU - Souery, Daniel

AU - Kozel, Dejan

AU - Preisig, Martin

AU - Lucae, Susanne

AU - Binder, Elisabeth B

AU - Aitchison, Katherine J

AU - Tozzi, Federica

AU - Muglia, Pierandrea

AU - Breen, Gerome

AU - Craig, Ian W

AU - Farmer, Anne E

AU - Müller-Myhsok, Bertram

AU - McGuffin, Peter

AU - Lewis, Cathryn M

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N2 - Genome-wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub-types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome-wide association data on 2,746 cases and 1,594 screened controls from the RADIANT studies, with replication performed in 1,471 cases and 1,403 controls from two Munich studies. Three methods were used to analyze AAO: First a time-to-event analysis with controls censored, secondly comparing controls to case-subsets defined using AAO cut-offs, and lastly analyzing AAO as a quantitative trait. In the time-to-event analysis three SNPs reached suggestive significance (P

AB - Genome-wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub-types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome-wide association data on 2,746 cases and 1,594 screened controls from the RADIANT studies, with replication performed in 1,471 cases and 1,403 controls from two Munich studies. Three methods were used to analyze AAO: First a time-to-event analysis with controls censored, secondly comparing controls to case-subsets defined using AAO cut-offs, and lastly analyzing AAO as a quantitative trait. In the time-to-event analysis three SNPs reached suggestive significance (P

U2 - 10.1002/ajmg.b.32093

DO - 10.1002/ajmg.b.32093

M3 - Article

C2 - 22915352

SN - 1552-4841

VL - 159B

SP - 859

EP - 868

JO - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics

IS - 7

ER -

Dissecting the genetic heterogeneity of depression through age at onset

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