Dissecting the genetic heterogeneity of depression through age at onset

Robert A Power, Robert Keers, Mandy Y Ng, Amy W Butler, Rudolf Uher, Sarah Cohen-Woods, Marcus Ising, Nick Craddock, Michael J Owen, Ania Korszun, Lisa Jones, Ian Jones, Michael Gill, John P Rice, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Astrid Zobel, Ole Mors, Anna S PlacentinoMarcella Rietschel, Daniel Souery, Dejan Kozel, Martin Preisig, Susanne Lucae, Elisabeth B Binder, Katherine J Aitchison, Federica Tozzi, Pierandrea Muglia, Gerome Breen, Ian W Craig, Anne E Farmer, Bertram Müller-Myhsok, Peter McGuffin, Cathryn M Lewis

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)


    Genome-wide studies in major depression have identified few replicated associations, potentially due to heterogeneity within the disorder. Several studies have suggested that age at onset (AAO) can distinguish sub-types of depression with specific heritable components. This paper investigates the role of AAO in the genetic susceptibility for depression using genome-wide association data on 2,746 cases and 1,594 screened controls from the RADIANT studies, with replication performed in 1,471 cases and 1,403 controls from two Munich studies. Three methods were used to analyze AAO: First a time-to-event analysis with controls censored, secondly comparing controls to case-subsets defined using AAO cut-offs, and lastly analyzing AAO as a quantitative trait. In the time-to-event analysis three SNPs reached suggestive significance (P 
    Original languageEnglish
    Pages (from-to)859-68
    Number of pages10
    JournalAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
    Issue number7
    Publication statusPublished - 2012


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