Dissecting Clonal Heterogeneity in AML

Jan Jacob Schuringa; Constanze Bonifer

doi:10.1016/j.ccell.2020.11.011

Dissecting Clonal Heterogeneity in AML

Jan Jacob Schuringa
, Constanze Bonifer

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

Abstract

Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

Original language	English
Pages (from-to)	782-784
Number of pages	3
Journal	Cancer Cell
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2020.11.011
Publication status	Published - 14 Dec 2020

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

Access to Document

10.1016/j.ccell.2020.11.011

Cite this

@article{2204189b9ec846e9987ffd89fe2921c7,

title = "Dissecting Clonal Heterogeneity in AML",

abstract = "Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.",

author = "Schuringa, \{Jan Jacob\} and Constanze Bonifer",

year = "2020",

month = dec,

day = "14",

doi = "10.1016/j.ccell.2020.11.011",

language = "English",

volume = "38",

pages = "782--784",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Dissecting Clonal Heterogeneity in AML

AU - Schuringa, Jan Jacob

AU - Bonifer, Constanze

PY - 2020/12/14

Y1 - 2020/12/14

N2 - Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

AB - Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

UR - https://www.scopus.com/pages/publications/85097466668

U2 - 10.1016/j.ccell.2020.11.011

DO - 10.1016/j.ccell.2020.11.011

M3 - Article

C2 - 33321087

SN - 1535-6108

VL - 38

SP - 782

EP - 784

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

Dissecting Clonal Heterogeneity in AML

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this