Dissecting Clonal Heterogeneity in AML

Jan Jacob Schuringa, Constanze Bonifer

Research output: Contribution to journalArticle


Using targeted single-cell DNA sequencing approaches, two articles in Nature and Nature Communications have now firmly established that acute myeloid leukemia is a highly dynamic oligoclonal disease. Clonal evolution during disease progression and therapy occurs in both linear and branched trajectories, with a clear order of mutational events.

Original languageEnglish
Pages (from-to)782-784
Number of pages3
JournalCancer Cell
Issue number6
Publication statusPublished - 14 Dec 2020


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