Direct observation of reversible biomolecule switching controlled by electrical stimulus

Alice Pranzetti, Matthew Davis, Chun-Ling Yeung, Jon A. Preece, Patrick Koelsch, Paula M. Mendes

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
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In situ sum-frequency-generation spectroscopy is used for the first time to study changes in molecular orientations in charged biofunctionalized self-assembled monolayers, in response to an applied electrical potential. The findings presented here unravel the mechanism by which charged biomolecules control biomolecular interactions, for example, protein binding affinities, and lay the foundation for future studies aiming to explore molecular conformational changes in response to electrical stimuli.
Original languageEnglish
Article number1400026
JournalAdvanced Materials Interfaces
Issue number5
Early online date4 Apr 2014
Publication statusPublished - 22 Aug 2014


  • switchable surfaces
  • self-assembled monolayers
  • sum frequency generation
  • electrochemistry


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