Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex

Alkomiet Hasan; Masashi Hamada; Michael A Nitsche; Diane Ruge; Joseph M Galea; Thomas Wobrock; John C Rothwell

doi:10.1007/s00221-011-2968-5

Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex

Alkomiet Hasan, Masashi Hamada, Michael A Nitsche, Diane Ruge, Joseph M Galea, Thomas Wobrock, John C Rothwell

Psychology

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29 Citations (Scopus)

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Abstract

Animal studies using polarising currents have shown that induction of synaptic long-term potentiation (LTP) and long-term depression (LTD) by bursts of patterned stimulation is affected by the membrane potential of the postsynaptic neurone. The aim of the present experiments was to test whether it is possible to observe similar phenomena in humans with the aim of improving present protocols of inducing synaptic plasticity for therapeutic purposes. We tested whether the LTP/LTD-like after effects of transcranial theta-burst stimulation (TBS) of human motor cortex, an analogue of patterned electrical stimulation in animals, were affected by simultaneous transcranial direct-current stimulation (tDCS), a non-invasive method of polarising cortical neurones in humans. Nine healthy volunteers were investigated in a single-blind, balanced cross-over study; continuous TBS (cTBS) was used to introduce LTD-like after effects, whereas intermittent TBS (iTBS) produced LTP-like effects. Each pattern was coupled with concurrent application of tDCS (

Original language	English
Pages (from-to)	15-23
Number of pages	9
Journal	Experimental Brain Research
Volume	217
Issue number	1
DOIs	https://doi.org/10.1007/s00221-011-2968-5
Publication status	Published - Mar 2012

Keywords

Adult
Cross-Over Studies
Electric Stimulation
Evoked Potentials, Motor
Female
Humans
Male
Motor Cortex
Nerve Net
Neuronal Plasticity
Neurons
Single-Blind Method
Transcranial Magnetic Stimulation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00221-011-2968-5

Hasan_Direct_Current_Dependent_Shift_Experimental_Brain_Research_2012
Eligibility for repository checked December 2014. Available under Creative Commons license.
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Centre for Musculoskeletal Ageing Research (linked to 18289 & 19482)
Lord, J., Buckley, C., Duda, J., Dunn, W., Miall, C. & Greig, C.
Medical Research Council
1/08/12 → 31/07/17
Project: Research Councils

Cite this

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title = "Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex",

abstract = "Animal studies using polarising currents have shown that induction of synaptic long-term potentiation (LTP) and long-term depression (LTD) by bursts of patterned stimulation is affected by the membrane potential of the postsynaptic neurone. The aim of the present experiments was to test whether it is possible to observe similar phenomena in humans with the aim of improving present protocols of inducing synaptic plasticity for therapeutic purposes. We tested whether the LTP/LTD-like after effects of transcranial theta-burst stimulation (TBS) of human motor cortex, an analogue of patterned electrical stimulation in animals, were affected by simultaneous transcranial direct-current stimulation (tDCS), a non-invasive method of polarising cortical neurones in humans. Nine healthy volunteers were investigated in a single-blind, balanced cross-over study; continuous TBS (cTBS) was used to introduce LTD-like after effects, whereas intermittent TBS (iTBS) produced LTP-like effects. Each pattern was coupled with concurrent application of tDCS (",

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AU - Hamada, Masashi

AU - Nitsche, Michael A

AU - Ruge, Diane

AU - Galea, Joseph M

AU - Wobrock, Thomas

AU - Rothwell, John C

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KW - Cross-Over Studies

KW - Electric Stimulation

KW - Evoked Potentials, Motor

KW - Female

KW - Humans

KW - Male

KW - Motor Cortex

KW - Nerve Net

KW - Neuronal Plasticity

KW - Neurons

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KW - Transcranial Magnetic Stimulation

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JO - Experimental Brain Research

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Direct-current-dependent shift of theta-burst-induced plasticity in the human motor cortex

Abstract

Keywords

UN SDGs

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Centre for Musculoskeletal Ageing Research (linked to 18289 & 19482)

Cite this