TY - JOUR
T1 - Diffusion tensor imaging and white matter abnormalities in patients with disorders of consciousness
AU - Cavaliere, Carlo
AU - Aiello, Marco
AU - Di Perri, Carol
AU - Fernandez-Espejo, Davinia
AU - Owen, Adrian M
AU - Soddu, Andrea
PY - 2015/1/6
Y1 - 2015/1/6
N2 - Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements of behavior, with an emerging role for neuroimaging techniques. In this review we focus on white matter alterations measured using Diffusion Tensor Imaging on patients with consciousness disorders, examining the most common diffusion imaging acquisition protocols and considering the main issues related to diffusion imaging analyses. We conclude by considering some of the remaining challenges to overcome, the existing knowledge gaps and the potential role of neuroimaging in understanding the pathogenesis and clinical features of disorders of consciousness.
AB - Progress in neuroimaging has yielded new powerful tools which, potentially, can be applied to clinical populations, improve the diagnosis of neurological disorders and predict outcome. At present, the diagnosis of consciousness disorders is limited to subjective assessment and objective measurements of behavior, with an emerging role for neuroimaging techniques. In this review we focus on white matter alterations measured using Diffusion Tensor Imaging on patients with consciousness disorders, examining the most common diffusion imaging acquisition protocols and considering the main issues related to diffusion imaging analyses. We conclude by considering some of the remaining challenges to overcome, the existing knowledge gaps and the potential role of neuroimaging in understanding the pathogenesis and clinical features of disorders of consciousness.
KW - coma
KW - brain
KW - diffusion tensor imaging
KW - consciousness
KW - tractography
U2 - 10.3389/fnhum.2014.01028
DO - 10.3389/fnhum.2014.01028
M3 - Review article
C2 - 25610388
SN - 1662-4548
VL - 8
SP - 1
EP - 7
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
M1 - 1028
ER -