Abstract
Significance: Invasive neuromonitoring hinders the application of diffuse optical tomography (DOT) to critically ill adults in the intensive care unit (ICU).
Aim: We aim to develop and test a method for DOT recordings suitable for traumatic brain injury (TBI) patients in the ICU. This method is based on measurements and coregistration using a 3D optical scan and the acquisition of optical data using a custom-made helmet, which would enable a multimodal (invasive and noninvasive) neuromonitoring.
Approach: Coregistration accuracy between the method based on a 3D optical scan and one based on an electromagnetic digitization, the latter considered to be the gold standard, was assessed. The capacity to isolate and monitor, using functional near-infrared spectroscopy, the optical signal in the intracranial (ICT), and extracranial tissues (ECT), was tested on 23 healthy volunteers. Participants were scanned with a frequency-domain NIRS device (690 and 830 nm) during 5 Valsalva maneuvers (VM) in a simulated ICU environment.
Results: The results showed an average error of coregistration of 5.5 mm and a sufficient capacity to isolate oxyhemoglobin (O2 Hb) (p = 6.4 ⋅ 10−6) and total hemoglobin (HbT) (p = 2.8 ⋅ 10−5) in the ICT from the ECT and to follow the changes of hemoglobin in the ICT during the VM (O2 Hb, p = 9.2 ⋅ 10−4; HbT, p = 1.0 ⋅ 10−3).
Conclusion: The developed approach appears to be suitable for use on TBI patients in the ICU in a multimodal monitoring.
Aim: We aim to develop and test a method for DOT recordings suitable for traumatic brain injury (TBI) patients in the ICU. This method is based on measurements and coregistration using a 3D optical scan and the acquisition of optical data using a custom-made helmet, which would enable a multimodal (invasive and noninvasive) neuromonitoring.
Approach: Coregistration accuracy between the method based on a 3D optical scan and one based on an electromagnetic digitization, the latter considered to be the gold standard, was assessed. The capacity to isolate and monitor, using functional near-infrared spectroscopy, the optical signal in the intracranial (ICT), and extracranial tissues (ECT), was tested on 23 healthy volunteers. Participants were scanned with a frequency-domain NIRS device (690 and 830 nm) during 5 Valsalva maneuvers (VM) in a simulated ICU environment.
Results: The results showed an average error of coregistration of 5.5 mm and a sufficient capacity to isolate oxyhemoglobin (O2 Hb) (p = 6.4 ⋅ 10−6) and total hemoglobin (HbT) (p = 2.8 ⋅ 10−5) in the ICT from the ECT and to follow the changes of hemoglobin in the ICT during the VM (O2 Hb, p = 9.2 ⋅ 10−4; HbT, p = 1.0 ⋅ 10−3).
Conclusion: The developed approach appears to be suitable for use on TBI patients in the ICU in a multimodal monitoring.
| Original language | English |
|---|---|
| Article number | S23912 |
| Number of pages | 18 |
| Journal | Journal of Biomedical Optics |
| Volume | 30 |
| Issue number | S2 |
| DOIs | |
| Publication status | Published - 17 Sept 2025 |