Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection

N D Jones, S E Turvey, A Van Maurik, M Hara, C I Kingsley, C H Smith, A L Mellor, P J Morris, K J Wood

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Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K(b+) skin and islet allografts to rejection is not based on their ability to activate more H-2K(b)-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2K(b)-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.
Original languageEnglish
Pages (from-to)2824-30
Number of pages7
JournalJournal of Immunology
Issue number4
Publication statusPublished - 15 Feb 2001


  • Animals
  • Islets of Langerhans Transplantation
  • Skin Transplantation
  • Mice, Transgenic
  • Lymphocyte Activation
  • Epitopes, T-Lymphocyte
  • Lymphocyte Count
  • Isoantigens
  • Graft Rejection
  • T-Lymphocytes, Cytotoxic
  • Male
  • Cell Movement
  • Disease Susceptibility
  • Heart Transplantation
  • Mice
  • Postoperative Period
  • Transplantation, Homologous
  • Immune Tolerance
  • Organ Transplantation
  • H-2 Antigens
  • Mice, Inbred CBA
  • Immunologic Memory
  • Mice, Inbred C57BL
  • Lymph Nodes
  • T-Lymphocyte Subsets


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