Abstract
Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K(b+) skin and islet allografts to rejection is not based on their ability to activate more H-2K(b)-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2K(b)-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.
Original language | English |
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Pages (from-to) | 2824-30 |
Number of pages | 7 |
Journal | Journal of Immunology |
Volume | 166 |
Issue number | 4 |
Publication status | Published - 15 Feb 2001 |
Keywords
- Animals
- Islets of Langerhans Transplantation
- Skin Transplantation
- Mice, Transgenic
- Lymphocyte Activation
- Epitopes, T-Lymphocyte
- Lymphocyte Count
- Isoantigens
- Graft Rejection
- T-Lymphocytes, Cytotoxic
- Male
- Cell Movement
- Disease Susceptibility
- Heart Transplantation
- Mice
- Postoperative Period
- Transplantation, Homologous
- Immune Tolerance
- Organ Transplantation
- H-2 Antigens
- Mice, Inbred CBA
- Immunologic Memory
- Mice, Inbred C57BL
- Lymph Nodes
- T-Lymphocyte Subsets