Differential impact of behavioral, social, and emotional apathy on Parkinson's disease

Yuen-Siang Ang, Patricia L Lockwood, Annika Kienast, Olivia Plant, Daniel Drew, Elitsa Slavkova, Marin Tamm, Masud Husain

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Apathy is highly prevalent in Parkinson's disease. New findings suggest the syndrome is multifaceted. Here, we investigate whether all aspects of apathy are equally affected in Parkinson's disease and whether different dimensions of apathy were associated with depression and anhedonia. On the Apathy Motivation Index, while behavioral apathy and social apathy were elevated, emotional motivation was relatively preserved in Parkinson's disease, although a few patients did show impaired emotional sensitivity. Behavioral and social, but not emotional, apathy was associated with depression and anhedonia. These findings suggest aspects of motivation can be selectively impaired in Parkinson's disease and may have implications for guiding treatment.

Original languageEnglish
Pages (from-to)1286-1291
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Volume5
Issue number10
DOIs
Publication statusPublished - Oct 2018
Externally publishedYes

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