Dietary changes and associations with metabolic improvements in adults with Type 2 diabetes during a patient-centred dietary intervention: an exploratory analysis

Clare England, Janice Thompson, Russ Jago, Ashley R Cooper, Rob C Andrews, Rosemary Greenwood, Debbie J Sharp

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
53 Downloads (Pure)

Abstract

Objectives Describe dietary intake of participants enrolled in a non-prescriptive dietary intervention and dietary changes at 6 months and explore whether these changes had a role in observed improvements in glycated haemoglobin (HbA1c), weight, lipids and blood pressure.Design Secondary analysis of data from the Early ACTivity in Diabetes randomised controlled trial.Participants 262 patients with newly diagnosed type 2 diabetes randomised to the dietary intervention.Outcomes and analysis Changes in energy intake, macronutrients, fibre and alcohol and in weight, waist circumference, lipids, HbA1c and blood pressure at baseline and 6 months. Multivariate models were used to examine associations between dietary changes and metabolic variables.Results Men reported reducing mean energy intake from 1903±462 kcal to 1685 kcal±439 kcal (p<0.001), increasing carbohydrate intake from 42.4±6.6% to 43.8±6.6% (p=0.002) and reducing median alcohol intake from 13 (0–27) g to 5 (0–18) g (p<0.001). Women reported reducing mean energy intake from 1582±379 kcal to 1459±326 kcal (p<0.001) with no change to macronutrient distribution and alcohol. Fibre intake was maintained. In men (n=148), weak and clinically insignificant associations were found between increased carbohydrates and reduction in HbA1c (β=−0.003 (−0.006, −0.001); p=0.009), increased fibre and reduction in total cholesterol (β=−0.023 (−0.044, −0.002); p=0.033), decreased total fat and reduction in low-density lipoprotein (LDL)-cholesterol (β=0.024 (0.006, 0.001); p=0.011), and decreased alcohol and reduction in diastolic blood pressure (β=0.276 (0.055, 0.497); p=0.015). In women (n=75), associations were found between a decrease in transfats and reductions in waist circumference (β=−0.029 (0.006, 0.052); p=0.015), total cholesterol (β=0.399 (0.028, 0.770); p=0.036) and LDL cholesterol (β=0.365 (0.042, 0.668); p=0.028).Conclusions Clinically important metabolic improvements observed in a patient-centred dietary intervention were not explained by changes in macronutrients. However, a non-prescriptive approach may promote a reduction in total energy intake while maintaining fibre consumption.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBMJ open
Volume4
Issue number6
DOIs
Publication statusPublished - 13 Jun 2014

Fingerprint

Dive into the research topics of 'Dietary changes and associations with metabolic improvements in adults with Type 2 diabetes during a patient-centred dietary intervention: an exploratory analysis'. Together they form a unique fingerprint.

Cite this